Drug interactions
Hydrochlorothiazide-losartan + Ombitasvir / paritaprevir / ritonavir and dasabuvir
Severity: Moderate
Hydrochlorothiazide-losartan and Ombitasvir / paritaprevir / ritonavir and dasabuvir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ritonavir-boosted regimens strongly inhibit CYP3A4 and paritaprevir inhibits OATP transporters, which can increase exposure to losartan. This may cause excess hypotension or worsening renal function.
What this interaction means in plain words
Hydrochlorothiazide-losartan and Ombitasvir / paritaprevir / ritonavir and dasabuvir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of CYP3A4 and hepatic transporters raises losartan exposure.
What to do
Consider a lower losartan dose and monitor blood pressure and renal function; reduce further or switch agents if hypotension or renal decline develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide-losartan
- Aliskiren + Hydrochlorothiazide-losartan Contraindicated
- Dofetilide + Hydrochlorothiazide-losartan Contraindicated
- Hydrochlorothiazide-losartan + Sparsentan Contraindicated
- Aceclofenac + Hydrochlorothiazide-losartan Major
- Aldesleukin + Hydrochlorothiazide-losartan Major
- Amifostine + Hydrochlorothiazide-losartan Major
Frequently asked questions
Can I take Hydrochlorothiazide-losartan with Ombitasvir / paritaprevir / ritonavir and dasabuvir?
MediHelp rates the interaction as moderate. Hydrochlorothiazide-losartan and Ombitasvir / paritaprevir / ritonavir and dasabuvir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ritonavir-boosted regimens strongly inhibit CYP3A4 and paritaprevir inhibits OATP transporters, which can increase exposure to losartan. This may cause excess hypotension or worsening renal function.
How serious is the interaction between Hydrochlorothiazide-losartan and Ombitasvir / paritaprevir / ritonavir and dasabuvir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider a lower losartan dose and monitor blood pressure and renal function; reduce further or switch agents if hypotension or renal decline develops.
What other medicines interact with Hydrochlorothiazide-losartan?
MediHelp also lists interactions of Hydrochlorothiazide-losartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-losartan page.
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