Drug interactions
Hydrochlorothiazide-losartan + Penicillin g aqueous
Severity: Minor
Hydrochlorothiazide-losartan and Penicillin g aqueous: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Penicillins and thiazides are both secreted by renal tubular organic anion transporters, so competition may slightly raise levels of either. This is rarely clinically important at usual doses.
What this interaction means in plain words
Hydrochlorothiazide-losartan and Penicillin g aqueous have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Competition for renal tubular secretion via organic anion transporters.
What to do
No routine adjustment; monitor renal function and electrolytes in patients on high-dose penicillin G.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Hydrochlorothiazide-losartan
- Aliskiren + Hydrochlorothiazide-losartan Contraindicated
- Dofetilide + Hydrochlorothiazide-losartan Contraindicated
- Hydrochlorothiazide-losartan + Sparsentan Contraindicated
- Aceclofenac + Hydrochlorothiazide-losartan Major
- Aldesleukin + Hydrochlorothiazide-losartan Major
- Amifostine + Hydrochlorothiazide-losartan Major
Frequently asked questions
Can I take Hydrochlorothiazide-losartan with Penicillin g aqueous?
MediHelp rates the interaction as minor. Hydrochlorothiazide-losartan and Penicillin g aqueous have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Penicillins and thiazides are both secreted by renal tubular organic anion transporters, so competition may slightly raise levels of either. This is rarely clinically important at usual doses.
How serious is the interaction between Hydrochlorothiazide-losartan and Penicillin g aqueous?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment; monitor renal function and electrolytes in patients on high-dose penicillin G.
What other medicines interact with Hydrochlorothiazide-losartan?
MediHelp also lists interactions of Hydrochlorothiazide-losartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-losartan page.
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