Drug interactions
Hydrochlorothiazide-losartan + Penicillin vk
Severity: Minor
Hydrochlorothiazide-losartan and Penicillin vk: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Hydrochlorothiazide is secreted by renal organic anion transporters and may compete with penicillin for tubular secretion, theoretically raising penicillin levels slightly. The effect is small and penicillin has a wide therapeutic margin.
What this interaction means in plain words
Hydrochlorothiazide-losartan and Penicillin vk have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Competition for renal tubular anionic secretion.
What to do
No action needed; monitor only in severe renal impairment.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Hydrochlorothiazide-losartan
- Aliskiren + Hydrochlorothiazide-losartan Contraindicated
- Dofetilide + Hydrochlorothiazide-losartan Contraindicated
- Hydrochlorothiazide-losartan + Sparsentan Contraindicated
- Aceclofenac + Hydrochlorothiazide-losartan Major
- Aldesleukin + Hydrochlorothiazide-losartan Major
- Amifostine + Hydrochlorothiazide-losartan Major
Frequently asked questions
Can I take Hydrochlorothiazide-losartan with Penicillin vk?
MediHelp rates the interaction as minor. Hydrochlorothiazide-losartan and Penicillin vk have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Hydrochlorothiazide is secreted by renal organic anion transporters and may compete with penicillin for tubular secretion, theoretically raising penicillin levels slightly. The effect is small and penicillin has a wide therapeutic margin.
How serious is the interaction between Hydrochlorothiazide-losartan and Penicillin vk?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No action needed; monitor only in severe renal impairment.
What other medicines interact with Hydrochlorothiazide-losartan?
MediHelp also lists interactions of Hydrochlorothiazide-losartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-losartan page.
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