Drug interactions
Hydrochlorothiazide-losartan + Procainamide
Severity: Moderate
Hydrochlorothiazide-losartan and Procainamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Hydrochlorothiazide may compete with procainamide for renal tubular secretion, raising procainamide and NAPA levels. Thiazide-induced hypokalemia or hypomagnesemia may also heighten proarrhythmic risk with procainamide.
What this interaction means in plain words
Hydrochlorothiazide-losartan and Procainamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Competition for renal tubular cationic secretion and electrolyte disturbances increasing QT risk.
What to do
Monitor procainamide and NAPA concentrations, ECG and serum potassium and magnesium; correct electrolytes.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide-losartan
- Aliskiren + Hydrochlorothiazide-losartan Contraindicated
- Dofetilide + Hydrochlorothiazide-losartan Contraindicated
- Hydrochlorothiazide-losartan + Sparsentan Contraindicated
- Aceclofenac + Hydrochlorothiazide-losartan Major
- Aldesleukin + Hydrochlorothiazide-losartan Major
- Amifostine + Hydrochlorothiazide-losartan Major
Frequently asked questions
Can I take Hydrochlorothiazide-losartan with Procainamide?
MediHelp rates the interaction as moderate. Hydrochlorothiazide-losartan and Procainamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Hydrochlorothiazide may compete with procainamide for renal tubular secretion, raising procainamide and NAPA levels. Thiazide-induced hypokalemia or hypomagnesemia may also heighten proarrhythmic risk with procainamide.
How serious is the interaction between Hydrochlorothiazide-losartan and Procainamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor procainamide and NAPA concentrations, ECG and serum potassium and magnesium; correct electrolytes.
What other medicines interact with Hydrochlorothiazide-losartan?
MediHelp also lists interactions of Hydrochlorothiazide-losartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-losartan page.
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