Drug interactions
Hydrochlorothiazide-losartan + Propranolol
Severity: Minor
Hydrochlorothiazide-losartan and Propranolol: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Propranolol adds to the blood pressure lowering of losartan and hydrochlorothiazide, which may be intended but can cause hypotension or bradycardia. Beta-blockers may also modestly raise potassium and can mask hypoglycaemia in patients on thiazides who are diabetic.
What this interaction means in plain words
Hydrochlorothiazide-losartan and Propranolol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Hydrochlorothiazide-losartan belongs to Cardiovascular; Propranolol belongs to Cardiovascular.
Why it happens
Additive antihypertensive effects through different mechanisms.
What to do
Monitor blood pressure and heart rate when starting or adjusting doses. Check potassium periodically.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Hydrochlorothiazide-losartan
- Aliskiren + Hydrochlorothiazide-losartan Contraindicated
- Dofetilide + Hydrochlorothiazide-losartan Contraindicated
- Hydrochlorothiazide-losartan + Sparsentan Contraindicated
- Aceclofenac + Hydrochlorothiazide-losartan Major
- Aldesleukin + Hydrochlorothiazide-losartan Major
- Amifostine + Hydrochlorothiazide-losartan Major
Other interactions of Propranolol
- Propranolol + Thioridazine Contraindicated
- Acebutolol + Propranolol Major
- Adrenaline-articaine + Propranolol Major
- Albuterol + Propranolol Major
- Amifostine + Propranolol Major
- Amiodarone + Propranolol Major
Frequently asked questions
Can I take Hydrochlorothiazide-losartan with Propranolol?
MediHelp rates the interaction as minor. Hydrochlorothiazide-losartan and Propranolol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Propranolol adds to the blood pressure lowering of losartan and hydrochlorothiazide, which may be intended but can cause hypotension or bradycardia. Beta-blockers may also modestly raise potassium and can mask hypoglycaemia in patients on thiazides who are diabetic.
How serious is the interaction between Hydrochlorothiazide-losartan and Propranolol?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate when starting or adjusting doses. Check potassium periodically.
What other medicines interact with Hydrochlorothiazide-losartan?
MediHelp also lists interactions of Hydrochlorothiazide-losartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-losartan page.
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