Drug interactions
Hydrochlorothiazide-losartan + Reishi
Severity: Minor
Hydrochlorothiazide-losartan and Reishi: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Reishi mushroom has been reported to have mild blood pressure lowering activity, which could add to the effect of antihypertensives. Evidence is limited and mostly theoretical.
What this interaction means in plain words
Hydrochlorothiazide-losartan and Reishi have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible additive hypotensive effect; mechanism not well established.
What to do
Monitor blood pressure if reishi supplements are started or stopped.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Hydrochlorothiazide-losartan
- Aliskiren + Hydrochlorothiazide-losartan Contraindicated
- Dofetilide + Hydrochlorothiazide-losartan Contraindicated
- Hydrochlorothiazide-losartan + Sparsentan Contraindicated
- Aceclofenac + Hydrochlorothiazide-losartan Major
- Aldesleukin + Hydrochlorothiazide-losartan Major
- Amifostine + Hydrochlorothiazide-losartan Major
Frequently asked questions
Can I take Hydrochlorothiazide-losartan with Reishi?
MediHelp rates the interaction as minor. Hydrochlorothiazide-losartan and Reishi have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Reishi mushroom has been reported to have mild blood pressure lowering activity, which could add to the effect of antihypertensives. Evidence is limited and mostly theoretical.
How serious is the interaction between Hydrochlorothiazide-losartan and Reishi?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure if reishi supplements are started or stopped.
What other medicines interact with Hydrochlorothiazide-losartan?
MediHelp also lists interactions of Hydrochlorothiazide-losartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-losartan page.
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