Drug interactions
Hydrochlorothiazide-losartan + Salicylates
Severity: Moderate
Hydrochlorothiazide-losartan and Salicylates: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Non-acetylated salicylates have weaker prostaglandin inhibition than other NSAIDs, but at higher doses they may still blunt the antihypertensive effect of losartan and hydrochlorothiazide. Renal function can decline in volume-depleted or elderly patients, and potassium balance may change.
What this interaction means in plain words
Hydrochlorothiazide-losartan and Salicylates can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Reduced synthesis of vasodilatory renal prostaglandins may impair renal perfusion and sodium excretion, opposing the effects of the angiotensin receptor blocker and thiazide.
What to do
Monitor blood pressure, serum creatinine and potassium when salicylates are used regularly at analgesic or anti-inflammatory doses. Ensure adequate hydration and use the lowest effective salicylate dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide-losartan
- Aliskiren + Hydrochlorothiazide-losartan Contraindicated
- Dofetilide + Hydrochlorothiazide-losartan Contraindicated
- Hydrochlorothiazide-losartan + Sparsentan Contraindicated
- Aceclofenac + Hydrochlorothiazide-losartan Major
- Aldesleukin + Hydrochlorothiazide-losartan Major
- Amifostine + Hydrochlorothiazide-losartan Major
Frequently asked questions
Can I take Hydrochlorothiazide-losartan with Salicylates?
MediHelp rates the interaction as moderate. Hydrochlorothiazide-losartan and Salicylates can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Non-acetylated salicylates have weaker prostaglandin inhibition than other NSAIDs, but at higher doses they may still blunt the antihypertensive effect of losartan and hydrochlorothiazide. Renal function can decline in volume-depleted or elderly patients, and potassium balance may change.
How serious is the interaction between Hydrochlorothiazide-losartan and Salicylates?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, serum creatinine and potassium when salicylates are used regularly at analgesic or anti-inflammatory doses. Ensure adequate hydration and use the lowest effective salicylate dose.
What other medicines interact with Hydrochlorothiazide-losartan?
MediHelp also lists interactions of Hydrochlorothiazide-losartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-losartan page.
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