Drug interactions
Hydrochlorothiazide-losartan + Sodium sulfate / ?magnesium sulfate / potassium chloride
Severity: Moderate
Hydrochlorothiazide-losartan and Sodium sulfate / ?magnesium sulfate / potassium chloride: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Osmotic bowel preparations cause fluid loss and electrolyte shifts. In patients taking a thiazide and an ARB, this raises the risk of dehydration, electrolyte disturbance, acute kidney injury and arrhythmias or seizures.
What this interaction means in plain words
Hydrochlorothiazide-losartan and Sodium sulfate / ?magnesium sulfate / potassium chloride can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive volume depletion and electrolyte disturbance from bowel cleansing, diuretic action and angiotensin receptor blockade reducing renal perfusion.
What to do
Ensure adequate fluid intake during bowel preparation and consider withholding the diuretic and ARB on the day of preparation. Check electrolytes and renal function in high-risk patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide-losartan
- Aliskiren + Hydrochlorothiazide-losartan Contraindicated
- Dofetilide + Hydrochlorothiazide-losartan Contraindicated
- Hydrochlorothiazide-losartan + Sparsentan Contraindicated
- Aceclofenac + Hydrochlorothiazide-losartan Major
- Aldesleukin + Hydrochlorothiazide-losartan Major
- Amifostine + Hydrochlorothiazide-losartan Major
Frequently asked questions
Can I take Hydrochlorothiazide-losartan with Sodium sulfate / ?magnesium sulfate / potassium chloride?
MediHelp rates the interaction as moderate. Hydrochlorothiazide-losartan and Sodium sulfate / ?magnesium sulfate / potassium chloride can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Osmotic bowel preparations cause fluid loss and electrolyte shifts. In patients taking a thiazide and an ARB, this raises the risk of dehydration, electrolyte disturbance, acute kidney injury and arrhythmias or seizures.
How serious is the interaction between Hydrochlorothiazide-losartan and Sodium sulfate / ?magnesium sulfate / potassium chloride?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Ensure adequate fluid intake during bowel preparation and consider withholding the diuretic and ARB on the day of preparation. Check electrolytes and renal function in high-risk patients.
What other medicines interact with Hydrochlorothiazide-losartan?
MediHelp also lists interactions of Hydrochlorothiazide-losartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-losartan page.
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