Drug interactions
Hydrochlorothiazide-losartan + Sodium sulfate / potassium chloride / magnesium sulfate / polyethylene glycol
Severity: Moderate
Hydrochlorothiazide-losartan and Sodium sulfate / potassium chloride / magnesium sulfate / polyethylene glycol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bowel preparation causes fluid and electrolyte loss, and thiazide diuretics add to volume depletion and electrolyte disturbance. Losartan may reduce kidney perfusion in volume depletion, raising the risk of acute kidney injury.
What this interaction means in plain words
Hydrochlorothiazide-losartan and Sodium sulfate / potassium chloride / magnesium sulfate / polyethylene glycol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive fluid and electrolyte depletion from the osmotic bowel preparation and the diuretic, with impaired renal autoregulation from angiotensin receptor blockade.
What to do
Consider holding the diuretic and losartan on the day of bowel preparation, and ensure adequate hydration. Check electrolytes and renal function in high-risk patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide-losartan
- Aliskiren + Hydrochlorothiazide-losartan Contraindicated
- Dofetilide + Hydrochlorothiazide-losartan Contraindicated
- Hydrochlorothiazide-losartan + Sparsentan Contraindicated
- Aceclofenac + Hydrochlorothiazide-losartan Major
- Aldesleukin + Hydrochlorothiazide-losartan Major
- Amifostine + Hydrochlorothiazide-losartan Major
Frequently asked questions
Can I take Hydrochlorothiazide-losartan with Sodium sulfate / potassium chloride / magnesium sulfate / polyethylene glycol?
MediHelp rates the interaction as moderate. Hydrochlorothiazide-losartan and Sodium sulfate / potassium chloride / magnesium sulfate / polyethylene glycol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Bowel preparation causes fluid and electrolyte loss, and thiazide diuretics add to volume depletion and electrolyte disturbance. Losartan may reduce kidney perfusion in volume depletion, raising the risk of acute kidney injury.
How serious is the interaction between Hydrochlorothiazide-losartan and Sodium sulfate / potassium chloride / magnesium sulfate / polyethylene glycol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider holding the diuretic and losartan on the day of bowel preparation, and ensure adequate hydration. Check electrolytes and renal function in high-risk patients.
What other medicines interact with Hydrochlorothiazide-losartan?
MediHelp also lists interactions of Hydrochlorothiazide-losartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-losartan page.
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