Drug interactions
Hydrochlorothiazide-losartan + Sodium sulfate / potassium sulfate / magnesium sulfate
Severity: Moderate
Hydrochlorothiazide-losartan and Sodium sulfate / potassium sulfate / magnesium sulfate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
This sulfate bowel preparation induces fluid and electrolyte losses. With a thiazide and an ARB, dehydration, electrolyte abnormalities and kidney injury are more likely.
What this interaction means in plain words
Hydrochlorothiazide-losartan and Sodium sulfate / potassium sulfate / magnesium sulfate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive volume depletion and electrolyte shifts from osmotic laxative effect, diuresis and reduced renal autoregulation under angiotensin receptor blockade.
What to do
Encourage adequate hydration and consider temporarily withholding the diuretic and ARB on the day of preparation. Check electrolytes and renal function in patients with renal impairment or the elderly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Hydrochlorothiazide-losartan and Sodium sulfate / potassium sulfate / magnesium sulfate, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Hydrochlorothiazide-losartan
- Aliskiren + Hydrochlorothiazide-losartan Contraindicated
- Dofetilide + Hydrochlorothiazide-losartan Contraindicated
- Hydrochlorothiazide-losartan + Sparsentan Contraindicated
- Aceclofenac + Hydrochlorothiazide-losartan Major
- Aldesleukin + Hydrochlorothiazide-losartan Major
- Amifostine + Hydrochlorothiazide-losartan Major
Frequently asked questions
Can I take Hydrochlorothiazide-losartan with Sodium sulfate / potassium sulfate / magnesium sulfate?
MediHelp rates the interaction as moderate. Hydrochlorothiazide-losartan and Sodium sulfate / potassium sulfate / magnesium sulfate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. This sulfate bowel preparation induces fluid and electrolyte losses. With a thiazide and an ARB, dehydration, electrolyte abnormalities and kidney injury are more likely.
How serious is the interaction between Hydrochlorothiazide-losartan and Sodium sulfate / potassium sulfate / magnesium sulfate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Encourage adequate hydration and consider temporarily withholding the diuretic and ARB on the day of preparation. Check electrolytes and renal function in patients with renal impairment or the elderly.
What other medicines interact with Hydrochlorothiazide-losartan?
MediHelp also lists interactions of Hydrochlorothiazide-losartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-losartan page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
