Drug interactions
Hydrochlorothiazide-losartan + Squill
Severity: Major
Hydrochlorothiazide-losartan and Squill: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Squill contains cardiac glycosides, and hydrochlorothiazide can cause hypokalemia and hypomagnesemia, which sensitise the heart to glycoside toxicity. This increases the risk of arrhythmias. Losartan may partly reduce potassium loss but does not remove the risk.
What this interaction means in plain words
Hydrochlorothiazide-losartan and Squill can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Thiazide-induced hypokalemia and hypomagnesemia increase myocardial sensitivity to cardiac glycosides.
What to do
Avoid squill where possible. If used, monitor potassium and magnesium, correct deficits, and watch for glycoside toxicity or arrhythmias.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Hydrochlorothiazide-losartan
- Aliskiren + Hydrochlorothiazide-losartan Contraindicated
- Dofetilide + Hydrochlorothiazide-losartan Contraindicated
- Hydrochlorothiazide-losartan + Sparsentan Contraindicated
- Aceclofenac + Hydrochlorothiazide-losartan Major
- Aldesleukin + Hydrochlorothiazide-losartan Major
- Amifostine + Hydrochlorothiazide-losartan Major
Frequently asked questions
Can I take Hydrochlorothiazide-losartan with Squill?
MediHelp rates the interaction as major. Hydrochlorothiazide-losartan and Squill can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Squill contains cardiac glycosides, and hydrochlorothiazide can cause hypokalemia and hypomagnesemia, which sensitise the heart to glycoside toxicity. This increases the risk of arrhythmias. Losartan may partly reduce potassium loss but does not remove the risk.
How serious is the interaction between Hydrochlorothiazide-losartan and Squill?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid squill where possible. If used, monitor potassium and magnesium, correct deficits, and watch for glycoside toxicity or arrhythmias.
What other medicines interact with Hydrochlorothiazide-losartan?
MediHelp also lists interactions of Hydrochlorothiazide-losartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-losartan page.
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