Drug interactions
Hydrochlorothiazide-losartan + Synthetic human angiotensin ii
Severity: Moderate
Hydrochlorothiazide-losartan and Synthetic human angiotensin ii: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Losartan blocks AT1 receptors and can blunt the pressor effect of exogenous angiotensin II used to treat vasodilatory shock. Higher doses of angiotensin II may be required to maintain blood pressure.
What this interaction means in plain words
Hydrochlorothiazide-losartan and Synthetic human angiotensin ii can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Competitive antagonism of angiotensin II at AT1 receptors.
What to do
Titrate angiotensin II to blood pressure response, expecting a possible higher requirement in patients on an ARB. Hold the ARB during critical illness with shock.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide-losartan
- Aliskiren + Hydrochlorothiazide-losartan Contraindicated
- Dofetilide + Hydrochlorothiazide-losartan Contraindicated
- Hydrochlorothiazide-losartan + Sparsentan Contraindicated
- Aceclofenac + Hydrochlorothiazide-losartan Major
- Aldesleukin + Hydrochlorothiazide-losartan Major
- Amifostine + Hydrochlorothiazide-losartan Major
Frequently asked questions
Can I take Hydrochlorothiazide-losartan with Synthetic human angiotensin ii?
MediHelp rates the interaction as moderate. Hydrochlorothiazide-losartan and Synthetic human angiotensin ii can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Losartan blocks AT1 receptors and can blunt the pressor effect of exogenous angiotensin II used to treat vasodilatory shock. Higher doses of angiotensin II may be required to maintain blood pressure.
How serious is the interaction between Hydrochlorothiazide-losartan and Synthetic human angiotensin ii?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Titrate angiotensin II to blood pressure response, expecting a possible higher requirement in patients on an ARB. Hold the ARB during critical illness with shock.
What other medicines interact with Hydrochlorothiazide-losartan?
MediHelp also lists interactions of Hydrochlorothiazide-losartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-losartan page.
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