Drug interactions
Hydrochlorothiazide-losartan + Temocillin
Severity: Minor
Hydrochlorothiazide-losartan and Temocillin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Temocillin is a beta-lactam eliminated by renal tubular secretion, and hydrochlorothiazide also uses tubular secretory pathways. A clinically meaningful change in levels is not well established. Temocillin sodium load and diuretic-induced electrolyte changes may be relevant.
What this interaction means in plain words
Hydrochlorothiazide-losartan and Temocillin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible competition for renal tubular secretion; not well characterized.
What to do
No dose change is routinely needed. Monitor electrolytes and renal function during prolonged therapy.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Hydrochlorothiazide-losartan
- Aliskiren + Hydrochlorothiazide-losartan Contraindicated
- Dofetilide + Hydrochlorothiazide-losartan Contraindicated
- Hydrochlorothiazide-losartan + Sparsentan Contraindicated
- Aceclofenac + Hydrochlorothiazide-losartan Major
- Aldesleukin + Hydrochlorothiazide-losartan Major
- Amifostine + Hydrochlorothiazide-losartan Major
Frequently asked questions
Can I take Hydrochlorothiazide-losartan with Temocillin?
MediHelp rates the interaction as minor. Hydrochlorothiazide-losartan and Temocillin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Temocillin is a beta-lactam eliminated by renal tubular secretion, and hydrochlorothiazide also uses tubular secretory pathways. A clinically meaningful change in levels is not well established. Temocillin sodium load and diuretic-induced electrolyte changes may be relevant.
How serious is the interaction between Hydrochlorothiazide-losartan and Temocillin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is routinely needed. Monitor electrolytes and renal function during prolonged therapy.
What other medicines interact with Hydrochlorothiazide-losartan?
MediHelp also lists interactions of Hydrochlorothiazide-losartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-losartan page.
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