Drug interactions
Hydrochlorothiazide-losartan + Terbutaline
Severity: Moderate
Hydrochlorothiazide-losartan and Terbutaline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Terbutaline and hydrochlorothiazide both lower serum potassium, so the combination may cause clinically relevant hypokalemia and arrhythmias, particularly with high-dose or systemic beta-agonist use. Losartan may partly offset this.
What this interaction means in plain words
Hydrochlorothiazide-losartan and Terbutaline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Hydrochlorothiazide-losartan belongs to Cardiovascular; Terbutaline belongs to Respiratory.
Why it happens
Beta-2 agonist driven intracellular potassium shift adds to thiazide-induced renal potassium loss.
What to do
Monitor serum potassium, particularly with systemic or high-dose terbutaline, and replace potassium if low.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide-losartan
- Aliskiren + Hydrochlorothiazide-losartan Contraindicated
- Dofetilide + Hydrochlorothiazide-losartan Contraindicated
- Hydrochlorothiazide-losartan + Sparsentan Contraindicated
- Aceclofenac + Hydrochlorothiazide-losartan Major
- Aldesleukin + Hydrochlorothiazide-losartan Major
- Amifostine + Hydrochlorothiazide-losartan Major
Other interactions of Terbutaline
Frequently asked questions
Can I take Hydrochlorothiazide-losartan with Terbutaline?
MediHelp rates the interaction as moderate. Hydrochlorothiazide-losartan and Terbutaline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Terbutaline and hydrochlorothiazide both lower serum potassium, so the combination may cause clinically relevant hypokalemia and arrhythmias, particularly with high-dose or systemic beta-agonist use. Losartan may partly offset this.
How serious is the interaction between Hydrochlorothiazide-losartan and Terbutaline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium, particularly with systemic or high-dose terbutaline, and replace potassium if low.
What other medicines interact with Hydrochlorothiazide-losartan?
MediHelp also lists interactions of Hydrochlorothiazide-losartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-losartan page.
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