Drug interactions
Hydrochlorothiazide-losartan + Umeclidinium bromide / vilanterol inhaled
Severity: Moderate
Hydrochlorothiazide-losartan and Umeclidinium bromide / vilanterol inhaled: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vilanterol, a long-acting beta-agonist, can lower serum potassium, and hydrochlorothiazide also causes potassium loss. Together they may cause hypokalemia and ECG changes, particularly if the beta-agonist dose is exceeded; losartan partly offsets potassium loss.
What this interaction means in plain words
Hydrochlorothiazide-losartan and Umeclidinium bromide / vilanterol inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive hypokalemia from beta-2 stimulated intracellular potassium shift and thiazide renal potassium loss.
What to do
Monitor serum potassium in patients with risk factors such as heart disease or high inhaler doses. Correct hypokalemia and keep the inhaler at the labeled dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide-losartan
- Aliskiren + Hydrochlorothiazide-losartan Contraindicated
- Dofetilide + Hydrochlorothiazide-losartan Contraindicated
- Hydrochlorothiazide-losartan + Sparsentan Contraindicated
- Aceclofenac + Hydrochlorothiazide-losartan Major
- Aldesleukin + Hydrochlorothiazide-losartan Major
- Amifostine + Hydrochlorothiazide-losartan Major
Frequently asked questions
Can I take Hydrochlorothiazide-losartan with Umeclidinium bromide / vilanterol inhaled?
MediHelp rates the interaction as moderate. Hydrochlorothiazide-losartan and Umeclidinium bromide / vilanterol inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Vilanterol, a long-acting beta-agonist, can lower serum potassium, and hydrochlorothiazide also causes potassium loss. Together they may cause hypokalemia and ECG changes, particularly if the beta-agonist dose is exceeded; losartan partly offsets potassium loss.
How serious is the interaction between Hydrochlorothiazide-losartan and Umeclidinium bromide / vilanterol inhaled?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium in patients with risk factors such as heart disease or high inhaler doses. Correct hypokalemia and keep the inhaler at the labeled dose.
What other medicines interact with Hydrochlorothiazide-losartan?
MediHelp also lists interactions of Hydrochlorothiazide-losartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-losartan page.
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