Drug interactions
Hydrochlorothiazide-olmesartan + Isoproterenol
Severity: Moderate
Hydrochlorothiazide-olmesartan and Isoproterenol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both hydrochlorothiazide and isoproterenol can lower serum potassium, so together they may cause clinically important hypokalemia. This raises the risk of arrhythmias, particularly in patients with cardiac disease.
What this interaction means in plain words
Hydrochlorothiazide-olmesartan and Isoproterenol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Hydrochlorothiazide-olmesartan belongs to Cardiovascular; Isoproterenol belongs to Respiratory.
Why it happens
Thiazides cause renal potassium loss while beta-2 stimulation by isoproterenol shifts potassium into cells, producing additive hypokalemia.
What to do
Monitor serum potassium and ECG when used together, and replace potassium as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide-olmesartan
- Aliskiren + Hydrochlorothiazide-olmesartan Contraindicated
- Dofetilide + Hydrochlorothiazide-olmesartan Contraindicated
- Hydrochlorothiazide-olmesartan + Sparsentan Contraindicated
- Acemetacin + Hydrochlorothiazide-olmesartan Major
- Amifostine + Hydrochlorothiazide-olmesartan Major
- Amiloride + Hydrochlorothiazide-olmesartan Major
Other interactions of Isoproterenol
Frequently asked questions
Can I take Hydrochlorothiazide-olmesartan with Isoproterenol?
MediHelp rates the interaction as moderate. Hydrochlorothiazide-olmesartan and Isoproterenol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both hydrochlorothiazide and isoproterenol can lower serum potassium, so together they may cause clinically important hypokalemia. This raises the risk of arrhythmias, particularly in patients with cardiac disease.
How serious is the interaction between Hydrochlorothiazide-olmesartan and Isoproterenol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and ECG when used together, and replace potassium as needed.
What other medicines interact with Hydrochlorothiazide-olmesartan?
MediHelp also lists interactions of Hydrochlorothiazide-olmesartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-olmesartan page.
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