Drug interactions
Hydrochlorothiazide-olmesartan + Nebivolol
Severity: Moderate
Hydrochlorothiazide-olmesartan and Nebivolol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nebivolol adds to the blood pressure lowering of olmesartan and hydrochlorothiazide, which is often therapeutic but may cause hypotension or bradycardia. The combination is generally well tolerated with monitoring.
What this interaction means in plain words
Hydrochlorothiazide-olmesartan and Nebivolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Hydrochlorothiazide-olmesartan belongs to Cardiovascular; Nebivolol belongs to Cardiovascular.
Why it happens
Additive antihypertensive effects through beta-1 blockade with nitric oxide-mediated vasodilation, angiotensin receptor blockade and diuresis.
What to do
Monitor blood pressure and heart rate when starting or adjusting doses. Reduce doses if symptomatic hypotension or bradycardia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide-olmesartan
- Aliskiren + Hydrochlorothiazide-olmesartan Contraindicated
- Dofetilide + Hydrochlorothiazide-olmesartan Contraindicated
- Hydrochlorothiazide-olmesartan + Sparsentan Contraindicated
- Acemetacin + Hydrochlorothiazide-olmesartan Major
- Amifostine + Hydrochlorothiazide-olmesartan Major
- Amiloride + Hydrochlorothiazide-olmesartan Major
Other interactions of Nebivolol
- Acebutolol + Nebivolol Major
- Aldesleukin + Nebivolol Major
- Amiodarone + Nebivolol Major
- Atenolol-chlorthalidone + Nebivolol Major
- Atenolol + Nebivolol Major
- Betaxolol + Nebivolol Major
Frequently asked questions
Can I take Hydrochlorothiazide-olmesartan with Nebivolol?
MediHelp rates the interaction as moderate. Hydrochlorothiazide-olmesartan and Nebivolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nebivolol adds to the blood pressure lowering of olmesartan and hydrochlorothiazide, which is often therapeutic but may cause hypotension or bradycardia. The combination is generally well tolerated with monitoring.
How serious is the interaction between Hydrochlorothiazide-olmesartan and Nebivolol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate when starting or adjusting doses. Reduce doses if symptomatic hypotension or bradycardia occurs.
What other medicines interact with Hydrochlorothiazide-olmesartan?
MediHelp also lists interactions of Hydrochlorothiazide-olmesartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-olmesartan page.
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