Drug interactions
Hydrochlorothiazide-olmesartan + Oliceridine
Severity: Moderate
Hydrochlorothiazide-olmesartan and Oliceridine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Opioids can cause hypotension and may promote water retention through antidiuretic hormone release, which could blunt diuretic effect. Additive hypotension, especially orthostatic, is also possible with antihypertensives.
What this interaction means in plain words
Hydrochlorothiazide-olmesartan and Oliceridine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Hydrochlorothiazide-olmesartan belongs to Cardiovascular; Oliceridine belongs to Musculoskeletal.
Why it happens
Opioid-induced histamine-related vasodilation and ADH release cause additive hypotension and reduced diuretic efficacy.
What to do
Monitor blood pressure, fluid status and urine output. Adjust the diuretic or antihypertensive dose as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide-olmesartan
- Aliskiren + Hydrochlorothiazide-olmesartan Contraindicated
- Dofetilide + Hydrochlorothiazide-olmesartan Contraindicated
- Hydrochlorothiazide-olmesartan + Sparsentan Contraindicated
- Acemetacin + Hydrochlorothiazide-olmesartan Major
- Amifostine + Hydrochlorothiazide-olmesartan Major
- Amiloride + Hydrochlorothiazide-olmesartan Major
Other interactions of Oliceridine
- Isocarboxazid + Oliceridine Contraindicated
- Alprazolam + Oliceridine Major
- Amiodarone + Oliceridine Major
- Amisulpride + Oliceridine Major
- Amitriptyline + Oliceridine Major
- Amobarbital + Oliceridine Major
Frequently asked questions
Can I take Hydrochlorothiazide-olmesartan with Oliceridine?
MediHelp rates the interaction as moderate. Hydrochlorothiazide-olmesartan and Oliceridine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Opioids can cause hypotension and may promote water retention through antidiuretic hormone release, which could blunt diuretic effect. Additive hypotension, especially orthostatic, is also possible with antihypertensives.
How serious is the interaction between Hydrochlorothiazide-olmesartan and Oliceridine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, fluid status and urine output. Adjust the diuretic or antihypertensive dose as needed.
What other medicines interact with Hydrochlorothiazide-olmesartan?
MediHelp also lists interactions of Hydrochlorothiazide-olmesartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-olmesartan page.
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