Drug interactions
Hydrochlorothiazide-olmesartan + Piperacillin
Severity: Minor
Hydrochlorothiazide-olmesartan and Piperacillin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Thiazides may slightly reduce renal elimination of piperacillin, and diuretic-induced hypokalemia can be worsened by piperacillin's sodium load and potassium wasting. Clinical impact is typically small.
What this interaction means in plain words
Hydrochlorothiazide-olmesartan and Piperacillin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Hydrochlorothiazide-olmesartan belongs to Cardiovascular; Piperacillin belongs to Anti Bacterial.
Why it happens
Possible competition for renal tubular secretion; additive potassium loss.
What to do
Monitor serum potassium and renal function during piperacillin therapy.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Hydrochlorothiazide-olmesartan and Piperacillin, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Hydrochlorothiazide-olmesartan
- Aliskiren + Hydrochlorothiazide-olmesartan Contraindicated
- Dofetilide + Hydrochlorothiazide-olmesartan Contraindicated
- Hydrochlorothiazide-olmesartan + Sparsentan Contraindicated
- Acemetacin + Hydrochlorothiazide-olmesartan Major
- Amifostine + Hydrochlorothiazide-olmesartan Major
- Amiloride + Hydrochlorothiazide-olmesartan Major
Other interactions of Piperacillin
- Piperacillin + Vancomycin Major
- Acetylsalicylic acid + Piperacillin Moderate
- Amikacin + Piperacillin Moderate
- Antithrombin alfa + Piperacillin Moderate
- Antithrombin iii + Piperacillin Moderate
- Argatroban + Piperacillin Moderate
Frequently asked questions
Can I take Hydrochlorothiazide-olmesartan with Piperacillin?
MediHelp rates the interaction as minor. Hydrochlorothiazide-olmesartan and Piperacillin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Thiazides may slightly reduce renal elimination of piperacillin, and diuretic-induced hypokalemia can be worsened by piperacillin's sodium load and potassium wasting. Clinical impact is typically small.
How serious is the interaction between Hydrochlorothiazide-olmesartan and Piperacillin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and renal function during piperacillin therapy.
What other medicines interact with Hydrochlorothiazide-olmesartan?
MediHelp also lists interactions of Hydrochlorothiazide-olmesartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-olmesartan page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
