Drug interactions
Hydrochlorothiazide-olmesartan + Prednisone
Severity: Moderate
Hydrochlorothiazide-olmesartan and Prednisone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents promote urinary potassium loss, so combined use can cause or worsen hypokalemia. Low potassium raises the risk of arrhythmia and muscle weakness, particularly with prolonged or high-dose steroid therapy.
What this interaction means in plain words
Hydrochlorothiazide-olmesartan and Prednisone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Hydrochlorothiazide-olmesartan belongs to Cardiovascular; Prednisone belongs to Endocrine.
Why it happens
Additive kaliuresis from thiazide-induced distal sodium delivery and glucocorticoid effects on renal potassium handling.
What to do
Check serum potassium periodically and replace potassium as needed during prolonged steroid courses.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide-olmesartan
- Aliskiren + Hydrochlorothiazide-olmesartan Contraindicated
- Dofetilide + Hydrochlorothiazide-olmesartan Contraindicated
- Hydrochlorothiazide-olmesartan + Sparsentan Contraindicated
- Acemetacin + Hydrochlorothiazide-olmesartan Major
- Amifostine + Hydrochlorothiazide-olmesartan Major
- Amiloride + Hydrochlorothiazide-olmesartan Major
Other interactions of Prednisone
- Bcg vaccine live + Prednisone Contraindicated
- Measles vaccine + Prednisone Contraindicated
- Mifepristone + Prednisone Contraindicated
- Prednisone + Radium-223 dichloride Contraindicated
- Prednisone + Smallpox vaccine live Contraindicated
- Adenovirus types 4 and 7 live + Prednisone Major
Frequently asked questions
Can I take Hydrochlorothiazide-olmesartan with Prednisone?
MediHelp rates the interaction as moderate. Hydrochlorothiazide-olmesartan and Prednisone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents promote urinary potassium loss, so combined use can cause or worsen hypokalemia. Low potassium raises the risk of arrhythmia and muscle weakness, particularly with prolonged or high-dose steroid therapy.
How serious is the interaction between Hydrochlorothiazide-olmesartan and Prednisone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check serum potassium periodically and replace potassium as needed during prolonged steroid courses.
What other medicines interact with Hydrochlorothiazide-olmesartan?
MediHelp also lists interactions of Hydrochlorothiazide-olmesartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-olmesartan page.
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