Drug interactions
Hydrochlorothiazide-olmesartan + Probenecid
Severity: Moderate
Hydrochlorothiazide-olmesartan and Probenecid: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Thiazides compete with probenecid for tubular secretion and can raise uric acid, working against probenecid's uricosuric purpose. Probenecid may also raise thiazide levels and reduce its own efficacy in gout.
What this interaction means in plain words
Hydrochlorothiazide-olmesartan and Probenecid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Hydrochlorothiazide-olmesartan belongs to Cardiovascular; Probenecid belongs to Genitourinary.
Why it happens
Competition for renal organic anion transport and thiazide-induced hyperuricemia opposing uricosuric action.
What to do
Monitor serum uric acid and gout control, and adjust the probenecid dose if needed. Consider an alternative antihypertensive if urate control is poor.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide-olmesartan
- Aliskiren + Hydrochlorothiazide-olmesartan Contraindicated
- Dofetilide + Hydrochlorothiazide-olmesartan Contraindicated
- Hydrochlorothiazide-olmesartan + Sparsentan Contraindicated
- Acemetacin + Hydrochlorothiazide-olmesartan Major
- Amifostine + Hydrochlorothiazide-olmesartan Major
- Amiloride + Hydrochlorothiazide-olmesartan Major
Other interactions of Probenecid
- Ketorolac intranasal + Probenecid Contraindicated
- Ketorolac + Probenecid Contraindicated
- Baricitinib + Probenecid Major
- Ceftazidime / avibactam + Probenecid Major
- Methotrexate + Probenecid Major
- Pralatrexate + Probenecid Major
Frequently asked questions
Can I take Hydrochlorothiazide-olmesartan with Probenecid?
MediHelp rates the interaction as moderate. Hydrochlorothiazide-olmesartan and Probenecid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Thiazides compete with probenecid for tubular secretion and can raise uric acid, working against probenecid's uricosuric purpose. Probenecid may also raise thiazide levels and reduce its own efficacy in gout.
How serious is the interaction between Hydrochlorothiazide-olmesartan and Probenecid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum uric acid and gout control, and adjust the probenecid dose if needed. Consider an alternative antihypertensive if urate control is poor.
What other medicines interact with Hydrochlorothiazide-olmesartan?
MediHelp also lists interactions of Hydrochlorothiazide-olmesartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-olmesartan page.
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