Drug interactions
Hydrochlorothiazide-olmesartan + Quinidine
Severity: Moderate
Hydrochlorothiazide-olmesartan and Quinidine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Quinidine competes for renal tubular secretion and could modestly alter hydrochlorothiazide exposure. Thiazide-induced hypokalemia or hypomagnesemia also predisposes patients to quinidine-related QT prolongation and torsades de pointes.
What this interaction means in plain words
Hydrochlorothiazide-olmesartan and Quinidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Hydrochlorothiazide-olmesartan belongs to Cardiovascular; Quinidine belongs to Anti Parasitic.
Why it happens
Thiazide-induced electrolyte depletion increases proarrhythmic risk of quinidine, with possible competition for tubular cation transport.
What to do
Monitor serum potassium and magnesium and correct deficiencies. Obtain an ECG to monitor the QT interval.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide-olmesartan
- Aliskiren + Hydrochlorothiazide-olmesartan Contraindicated
- Dofetilide + Hydrochlorothiazide-olmesartan Contraindicated
- Hydrochlorothiazide-olmesartan + Sparsentan Contraindicated
- Acemetacin + Hydrochlorothiazide-olmesartan Major
- Amifostine + Hydrochlorothiazide-olmesartan Major
- Amiloride + Hydrochlorothiazide-olmesartan Major
Other interactions of Quinidine
- Adagrasib + Quinidine Contraindicated
- Arsenic trioxide + Quinidine Contraindicated
- Artemether / lumefantrine + Quinidine Contraindicated
- Chloroquine + Quinidine Contraindicated
- Dofetilide + Quinidine Contraindicated
- Dronedarone + Quinidine Contraindicated
Frequently asked questions
Can I take Hydrochlorothiazide-olmesartan with Quinidine?
MediHelp rates the interaction as moderate. Hydrochlorothiazide-olmesartan and Quinidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Quinidine competes for renal tubular secretion and could modestly alter hydrochlorothiazide exposure. Thiazide-induced hypokalemia or hypomagnesemia also predisposes patients to quinidine-related QT prolongation and torsades de pointes.
How serious is the interaction between Hydrochlorothiazide-olmesartan and Quinidine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and magnesium and correct deficiencies. Obtain an ECG to monitor the QT interval.
What other medicines interact with Hydrochlorothiazide-olmesartan?
MediHelp also lists interactions of Hydrochlorothiazide-olmesartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-olmesartan page.
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