Drug interactions
Hydrochlorothiazide-olmesartan + Repaglinide
Severity: Minor
Hydrochlorothiazide-olmesartan and Repaglinide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Thiazide diuretics can raise blood glucose and may weaken the effect of repaglinide. The effect is usually modest.
What this interaction means in plain words
Hydrochlorothiazide-olmesartan and Repaglinide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Hydrochlorothiazide-olmesartan belongs to Cardiovascular; Repaglinide belongs to Endocrine.
Why it happens
Thiazides impair insulin secretion and sensitivity, opposing repaglinide.
What to do
Monitor blood glucose and adjust the antidiabetic regimen if control deteriorates.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Hydrochlorothiazide-olmesartan
- Aliskiren + Hydrochlorothiazide-olmesartan Contraindicated
- Dofetilide + Hydrochlorothiazide-olmesartan Contraindicated
- Hydrochlorothiazide-olmesartan + Sparsentan Contraindicated
- Acemetacin + Hydrochlorothiazide-olmesartan Major
- Amifostine + Hydrochlorothiazide-olmesartan Major
- Amiloride + Hydrochlorothiazide-olmesartan Major
Other interactions of Repaglinide
- Gemfibrozil + Repaglinide Contraindicated
- Clarithromycin + Repaglinide Major
- Clopidogrel + Repaglinide Major
- Cobicistat + Repaglinide Major
- Cyclosporine + Repaglinide Major
- Cyclosporin + Repaglinide Major
Frequently asked questions
Can I take Hydrochlorothiazide-olmesartan with Repaglinide?
MediHelp rates the interaction as minor. Hydrochlorothiazide-olmesartan and Repaglinide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Thiazide diuretics can raise blood glucose and may weaken the effect of repaglinide. The effect is usually modest.
How serious is the interaction between Hydrochlorothiazide-olmesartan and Repaglinide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and adjust the antidiabetic regimen if control deteriorates.
What other medicines interact with Hydrochlorothiazide-olmesartan?
MediHelp also lists interactions of Hydrochlorothiazide-olmesartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-olmesartan page.
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