Drug interactions
Hydrochlorothiazide-olmesartan + Sulindac
Severity: Moderate
Hydrochlorothiazide-olmesartan and Sulindac: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sulindac can reduce the antihypertensive effect of olmesartan and hydrochlorothiazide. The combination of NSAID, ARB and diuretic raises the risk of acute kidney injury and hyperkalemia, particularly in older or volume-depleted patients. Sulindac may have less renal prostaglandin effect than other NSAIDs, but the risk remains.
What this interaction means in plain words
Hydrochlorothiazide-olmesartan and Sulindac can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Hydrochlorothiazide-olmesartan belongs to Cardiovascular; Sulindac belongs to Musculoskeletal.
Why it happens
NSAID inhibition of renal prostaglandin synthesis reduces renal perfusion and sodium excretion, opposing antihypertensive effects and adding to renal hemodynamic risk.
What to do
Use the lowest effective dose for the shortest time and maintain hydration. Monitor blood pressure, creatinine and potassium.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide-olmesartan
- Aliskiren + Hydrochlorothiazide-olmesartan Contraindicated
- Dofetilide + Hydrochlorothiazide-olmesartan Contraindicated
- Hydrochlorothiazide-olmesartan + Sparsentan Contraindicated
- Acemetacin + Hydrochlorothiazide-olmesartan Major
- Amifostine + Hydrochlorothiazide-olmesartan Major
- Amiloride + Hydrochlorothiazide-olmesartan Major
Other interactions of Sulindac
- Ketorolac intranasal + Sulindac Contraindicated
- Ketorolac + Sulindac Contraindicated
- Aceclofenac + Sulindac Major
- Acetylsalicylic acid + Sulindac Major
- Alteplase + Sulindac Major
- Amiloride + Sulindac Major
Frequently asked questions
Can I take Hydrochlorothiazide-olmesartan with Sulindac?
MediHelp rates the interaction as moderate. Hydrochlorothiazide-olmesartan and Sulindac can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sulindac can reduce the antihypertensive effect of olmesartan and hydrochlorothiazide. The combination of NSAID, ARB and diuretic raises the risk of acute kidney injury and hyperkalemia, particularly in older or volume-depleted patients. Sulindac may have less renal prostaglandin effect than other NSAIDs, but the risk remains.
How serious is the interaction between Hydrochlorothiazide-olmesartan and Sulindac?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective dose for the shortest time and maintain hydration. Monitor blood pressure, creatinine and potassium.
What other medicines interact with Hydrochlorothiazide-olmesartan?
MediHelp also lists interactions of Hydrochlorothiazide-olmesartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-olmesartan page.
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