Drug interactions
Hydrochlorothiazide-olmesartan + Tolbutamide
Severity: Moderate
Hydrochlorothiazide-olmesartan and Tolbutamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Hydrochlorothiazide can raise blood glucose and reduce the effectiveness of sulfonylureas such as tolbutamide, potentially worsening glycemic control. The effect is dose related and often modest.
What this interaction means in plain words
Hydrochlorothiazide-olmesartan and Tolbutamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Hydrochlorothiazide-olmesartan belongs to Cardiovascular; Tolbutamide belongs to Endocrine.
Why it happens
Thiazide-induced hypokalemia, reduced insulin release and decreased insulin sensitivity oppose the hypoglycemic action of the sulfonylurea.
What to do
Monitor blood glucose after starting or adjusting the thiazide, and increase the sulfonylurea dose or add therapy if needed. Keep serum potassium in range.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide-olmesartan
- Aliskiren + Hydrochlorothiazide-olmesartan Contraindicated
- Dofetilide + Hydrochlorothiazide-olmesartan Contraindicated
- Hydrochlorothiazide-olmesartan + Sparsentan Contraindicated
- Acemetacin + Hydrochlorothiazide-olmesartan Major
- Amifostine + Hydrochlorothiazide-olmesartan Major
- Amiloride + Hydrochlorothiazide-olmesartan Major
Other interactions of Tolbutamide
- Glyburide-metformin + Tolbutamide Major
- Insulin degludec-liraglutide + Tolbutamide Major
- Aceclofenac + Tolbutamide Moderate
- Acemetacin + Tolbutamide Moderate
- Acetylsalicylic acid + Tolbutamide Moderate
- Albiglutide + Tolbutamide Moderate
Frequently asked questions
Can I take Hydrochlorothiazide-olmesartan with Tolbutamide?
MediHelp rates the interaction as moderate. Hydrochlorothiazide-olmesartan and Tolbutamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Hydrochlorothiazide can raise blood glucose and reduce the effectiveness of sulfonylureas such as tolbutamide, potentially worsening glycemic control. The effect is dose related and often modest.
How serious is the interaction between Hydrochlorothiazide-olmesartan and Tolbutamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose after starting or adjusting the thiazide, and increase the sulfonylurea dose or add therapy if needed. Keep serum potassium in range.
What other medicines interact with Hydrochlorothiazide-olmesartan?
MediHelp also lists interactions of Hydrochlorothiazide-olmesartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-olmesartan page.
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