Drug interactions
Hydrochlorothiazide-telmisartan + Insulin degludec
Severity: Moderate
Hydrochlorothiazide-telmisartan and Insulin degludec: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Hydrochlorothiazide can raise blood glucose and reduce the effect of insulin in diabetic patients. Telmisartan may in contrast increase insulin sensitivity, so glucose control can shift in either direction after starting or stopping the combination.
What this interaction means in plain words
Hydrochlorothiazide-telmisartan and Insulin degludec can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Hydrochlorothiazide-telmisartan belongs to Cardiovascular; Insulin degludec belongs to Endocrine.
Why it happens
Thiazides impair glucose tolerance via hypokalemia and reduced insulin release, while ARBs may improve insulin sensitivity.
What to do
Monitor glucose and HbA1c after starting or changing the product, and adjust the insulin dose as needed. Keep potassium in the normal range.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide-telmisartan
- Aliskiren + Hydrochlorothiazide-telmisartan Contraindicated
- Dofetilide + Hydrochlorothiazide-telmisartan Contraindicated
- Hydrochlorothiazide-telmisartan + Sparsentan Contraindicated
- Aldesleukin + Hydrochlorothiazide-telmisartan Major
- Amifostine + Hydrochlorothiazide-telmisartan Major
- Amiloride + Hydrochlorothiazide-telmisartan Major
Other interactions of Insulin degludec
Frequently asked questions
Can I take Hydrochlorothiazide-telmisartan with Insulin degludec?
MediHelp rates the interaction as moderate. Hydrochlorothiazide-telmisartan and Insulin degludec can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Hydrochlorothiazide can raise blood glucose and reduce the effect of insulin in diabetic patients. Telmisartan may in contrast increase insulin sensitivity, so glucose control can shift in either direction after starting or stopping the combination.
How serious is the interaction between Hydrochlorothiazide-telmisartan and Insulin degludec?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor glucose and HbA1c after starting or changing the product, and adjust the insulin dose as needed. Keep potassium in the normal range.
What other medicines interact with Hydrochlorothiazide-telmisartan?
MediHelp also lists interactions of Hydrochlorothiazide-telmisartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-telmisartan page.
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