Drug interactions
Hydrochlorothiazide-telmisartan + Lofexidine
Severity: Moderate
Hydrochlorothiazide-telmisartan and Lofexidine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lofexidine lowers blood pressure and heart rate, and the antihypertensive components of this combination add to those effects. This may cause excessive hypotension, bradycardia and syncope, especially during opioid withdrawal treatment.
What this interaction means in plain words
Hydrochlorothiazide-telmisartan and Lofexidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Hydrochlorothiazide-telmisartan belongs to Cardiovascular; Lofexidine belongs to Central Nervous System.
Why it happens
Additive hypotensive and bradycardic effects from central alpha-2 agonism plus diuretic and angiotensin receptor blockade.
What to do
Monitor blood pressure and pulse before each dose and hold or reduce lofexidine or the antihypertensives for symptomatic hypotension or bradycardia. Counsel patients about orthostatic dizziness.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide-telmisartan
- Aliskiren + Hydrochlorothiazide-telmisartan Contraindicated
- Dofetilide + Hydrochlorothiazide-telmisartan Contraindicated
- Hydrochlorothiazide-telmisartan + Sparsentan Contraindicated
- Aldesleukin + Hydrochlorothiazide-telmisartan Major
- Amifostine + Hydrochlorothiazide-telmisartan Major
- Amiloride + Hydrochlorothiazide-telmisartan Major
Other interactions of Lofexidine
- Adagrasib + Lofexidine Major
- Alfuzosin + Lofexidine Major
- Amiodarone + Lofexidine Major
- Amisulpride + Lofexidine Major
- Anagrelide + Lofexidine Major
- Apomorphine + Lofexidine Major
Frequently asked questions
Can I take Hydrochlorothiazide-telmisartan with Lofexidine?
MediHelp rates the interaction as moderate. Hydrochlorothiazide-telmisartan and Lofexidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lofexidine lowers blood pressure and heart rate, and the antihypertensive components of this combination add to those effects. This may cause excessive hypotension, bradycardia and syncope, especially during opioid withdrawal treatment.
How serious is the interaction between Hydrochlorothiazide-telmisartan and Lofexidine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and pulse before each dose and hold or reduce lofexidine or the antihypertensives for symptomatic hypotension or bradycardia. Counsel patients about orthostatic dizziness.
What other medicines interact with Hydrochlorothiazide-telmisartan?
MediHelp also lists interactions of Hydrochlorothiazide-telmisartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-telmisartan page.
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