Drug interactions
Hydrochlorothiazide-telmisartan + Meloxicam
Severity: Major
Hydrochlorothiazide-telmisartan and Meloxicam: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Meloxicam can reduce the antihypertensive effect of telmisartan and hydrochlorothiazide and raises the risk of acute kidney injury and hyperkalemia. Elderly and volume-depleted patients are most vulnerable.
What this interaction means in plain words
Hydrochlorothiazide-telmisartan and Meloxicam can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Hydrochlorothiazide-telmisartan belongs to Cardiovascular; Meloxicam belongs to Musculoskeletal.
Why it happens
NSAID inhibition of renal prostaglandin synthesis causes sodium retention and reduced glomerular filtration in combination with ARB and diuretic.
What to do
Use the lowest effective NSAID dose for the shortest time or choose an alternative analgesic. Monitor blood pressure, creatinine and potassium and maintain hydration.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Hydrochlorothiazide-telmisartan
- Aliskiren + Hydrochlorothiazide-telmisartan Contraindicated
- Dofetilide + Hydrochlorothiazide-telmisartan Contraindicated
- Hydrochlorothiazide-telmisartan + Sparsentan Contraindicated
- Aldesleukin + Hydrochlorothiazide-telmisartan Major
- Amifostine + Hydrochlorothiazide-telmisartan Major
- Amiloride + Hydrochlorothiazide-telmisartan Major
Other interactions of Meloxicam
- Ketorolac intranasal + Meloxicam Contraindicated
- Ketorolac + Meloxicam Contraindicated
- Aceclofenac + Meloxicam Major
- Acemetacin + Meloxicam Major
- Acetylsalicylic acid + Meloxicam Major
- Alteplase + Meloxicam Major
Frequently asked questions
Can I take Hydrochlorothiazide-telmisartan with Meloxicam?
MediHelp rates the interaction as major. Hydrochlorothiazide-telmisartan and Meloxicam can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Meloxicam can reduce the antihypertensive effect of telmisartan and hydrochlorothiazide and raises the risk of acute kidney injury and hyperkalemia. Elderly and volume-depleted patients are most vulnerable.
How serious is the interaction between Hydrochlorothiazide-telmisartan and Meloxicam?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective NSAID dose for the shortest time or choose an alternative analgesic. Monitor blood pressure, creatinine and potassium and maintain hydration.
What other medicines interact with Hydrochlorothiazide-telmisartan?
MediHelp also lists interactions of Hydrochlorothiazide-telmisartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-telmisartan page.
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