Drug interactions
Hydrochlorothiazide-telmisartan + Ofloxacin
Severity: Minor
Hydrochlorothiazide-telmisartan and Ofloxacin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ofloxacin is mainly cleared by the kidney, and thiazides could theoretically slightly reduce its clearance. No clinically meaningful consequence is expected in most patients.
What this interaction means in plain words
Hydrochlorothiazide-telmisartan and Ofloxacin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Hydrochlorothiazide-telmisartan belongs to Cardiovascular; Ofloxacin belongs to Anti Bacterial.
Why it happens
Theoretical competition for renal tubular secretion, or reduced clearance from volume depletion.
What to do
No action is usually required. Consider the risk of QT prolongation if electrolyte disturbances such as hypokalemia occur, and check electrolytes if the patient is at risk.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Hydrochlorothiazide-telmisartan
- Aliskiren + Hydrochlorothiazide-telmisartan Contraindicated
- Dofetilide + Hydrochlorothiazide-telmisartan Contraindicated
- Hydrochlorothiazide-telmisartan + Sparsentan Contraindicated
- Aldesleukin + Hydrochlorothiazide-telmisartan Major
- Amifostine + Hydrochlorothiazide-telmisartan Major
- Amiloride + Hydrochlorothiazide-telmisartan Major
Other interactions of Ofloxacin
- Ofloxacin + Thioridazine Contraindicated
- Adagrasib + Ofloxacin Major
- Amiodarone + Ofloxacin Major
- Amisulpride + Ofloxacin Major
- Anagrelide + Ofloxacin Major
- Arsenic trioxide + Ofloxacin Major
Frequently asked questions
Can I take Hydrochlorothiazide-telmisartan with Ofloxacin?
MediHelp rates the interaction as minor. Hydrochlorothiazide-telmisartan and Ofloxacin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Ofloxacin is mainly cleared by the kidney, and thiazides could theoretically slightly reduce its clearance. No clinically meaningful consequence is expected in most patients.
How serious is the interaction between Hydrochlorothiazide-telmisartan and Ofloxacin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No action is usually required. Consider the risk of QT prolongation if electrolyte disturbances such as hypokalemia occur, and check electrolytes if the patient is at risk.
What other medicines interact with Hydrochlorothiazide-telmisartan?
MediHelp also lists interactions of Hydrochlorothiazide-telmisartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-telmisartan page.
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