Drug interactions
Hydrochlorothiazide-telmisartan + Pioglitazone
Severity: Minor
Hydrochlorothiazide-telmisartan and Pioglitazone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Thiazide diuretics can increase blood glucose and may weaken the glucose-lowering effect of pioglitazone. The effect is usually small at low hydrochlorothiazide doses.
What this interaction means in plain words
Hydrochlorothiazide-telmisartan and Pioglitazone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Hydrochlorothiazide-telmisartan belongs to Cardiovascular; Pioglitazone belongs to Endocrine.
Why it happens
Thiazide-induced impairment of glucose tolerance opposes the insulin-sensitizing effect.
What to do
Monitor blood glucose when starting or adjusting the thiazide and adjust antidiabetic therapy if needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Hydrochlorothiazide-telmisartan
- Aliskiren + Hydrochlorothiazide-telmisartan Contraindicated
- Dofetilide + Hydrochlorothiazide-telmisartan Contraindicated
- Hydrochlorothiazide-telmisartan + Sparsentan Contraindicated
- Aldesleukin + Hydrochlorothiazide-telmisartan Major
- Amifostine + Hydrochlorothiazide-telmisartan Major
- Amiloride + Hydrochlorothiazide-telmisartan Major
Other interactions of Pioglitazone
Frequently asked questions
Can I take Hydrochlorothiazide-telmisartan with Pioglitazone?
MediHelp rates the interaction as minor. Hydrochlorothiazide-telmisartan and Pioglitazone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Thiazide diuretics can increase blood glucose and may weaken the glucose-lowering effect of pioglitazone. The effect is usually small at low hydrochlorothiazide doses.
How serious is the interaction between Hydrochlorothiazide-telmisartan and Pioglitazone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when starting or adjusting the thiazide and adjust antidiabetic therapy if needed.
What other medicines interact with Hydrochlorothiazide-telmisartan?
MediHelp also lists interactions of Hydrochlorothiazide-telmisartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-telmisartan page.
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