Drug interactions
Hydrochlorothiazide-telmisartan + Salmeterol
Severity: Moderate
Hydrochlorothiazide-telmisartan and Salmeterol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Salmeterol and hydrochlorothiazide can each lower serum potassium, and the effect may be additive, especially at higher beta-agonist doses. Hypokalemia can promote arrhythmias, particularly in patients with cardiac disease or hypoxia.
What this interaction means in plain words
Hydrochlorothiazide-telmisartan and Salmeterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Hydrochlorothiazide-telmisartan belongs to Cardiovascular; Salmeterol belongs to Respiratory.
Why it happens
Beta-2 agonist driven intracellular potassium shift combined with thiazide urinary potassium loss.
What to do
Monitor serum potassium in patients with heart disease or on high doses. Replace potassium if needed; telmisartan partly offsets the loss.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide-telmisartan
- Aliskiren + Hydrochlorothiazide-telmisartan Contraindicated
- Dofetilide + Hydrochlorothiazide-telmisartan Contraindicated
- Hydrochlorothiazide-telmisartan + Sparsentan Contraindicated
- Aldesleukin + Hydrochlorothiazide-telmisartan Major
- Amifostine + Hydrochlorothiazide-telmisartan Major
- Amiloride + Hydrochlorothiazide-telmisartan Major
Other interactions of Salmeterol
- Ritonavir + Salmeterol Contraindicated
- Salmeterol + Saquinavir Contraindicated
- Amitriptyline + Salmeterol Major
- Arformoterol + Salmeterol Major
- Atazanavir + Salmeterol Major
- Budesonide-formoterol + Salmeterol Major
Frequently asked questions
Can I take Hydrochlorothiazide-telmisartan with Salmeterol?
MediHelp rates the interaction as moderate. Hydrochlorothiazide-telmisartan and Salmeterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Salmeterol and hydrochlorothiazide can each lower serum potassium, and the effect may be additive, especially at higher beta-agonist doses. Hypokalemia can promote arrhythmias, particularly in patients with cardiac disease or hypoxia.
How serious is the interaction between Hydrochlorothiazide-telmisartan and Salmeterol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium in patients with heart disease or on high doses. Replace potassium if needed; telmisartan partly offsets the loss.
What other medicines interact with Hydrochlorothiazide-telmisartan?
MediHelp also lists interactions of Hydrochlorothiazide-telmisartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-telmisartan page.
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