Drug interactions
Hydrochlorothiazide-telmisartan + Valsartan
Severity: Major
Hydrochlorothiazide-telmisartan and Valsartan: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Valsartan and telmisartan are both angiotensin receptor blockers, so combining them duplicates therapy. This increases the risk of hypotension, hyperkalemia and renal dysfunction without proven additional benefit.
What this interaction means in plain words
Hydrochlorothiazide-telmisartan and Valsartan can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Hydrochlorothiazide-telmisartan belongs to Cardiovascular; Valsartan belongs to Cardiovascular.
Why it happens
Dual angiotensin II receptor blockade causing excessive inhibition of the renin-angiotensin system.
What to do
Avoid combining two angiotensin receptor blockers and use only one agent. If already combined, monitor potassium, creatinine and blood pressure and stop one.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Hydrochlorothiazide-telmisartan
- Aliskiren + Hydrochlorothiazide-telmisartan Contraindicated
- Dofetilide + Hydrochlorothiazide-telmisartan Contraindicated
- Hydrochlorothiazide-telmisartan + Sparsentan Contraindicated
- Aldesleukin + Hydrochlorothiazide-telmisartan Major
- Amifostine + Hydrochlorothiazide-telmisartan Major
- Amiloride + Hydrochlorothiazide-telmisartan Major
Other interactions of Valsartan
- Aliskiren + Valsartan Contraindicated
- Sparsentan + Valsartan Contraindicated
- Aldesleukin + Valsartan Major
- Amifostine + Valsartan Major
- Amiloride + Valsartan Major
- Amlodipine-benazepril + Valsartan Major
Frequently asked questions
Can I take Hydrochlorothiazide-telmisartan with Valsartan?
MediHelp rates the interaction as major. Hydrochlorothiazide-telmisartan and Valsartan can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Valsartan and telmisartan are both angiotensin receptor blockers, so combining them duplicates therapy. This increases the risk of hypotension, hyperkalemia and renal dysfunction without proven additional benefit.
How serious is the interaction between Hydrochlorothiazide-telmisartan and Valsartan?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining two angiotensin receptor blockers and use only one agent. If already combined, monitor potassium, creatinine and blood pressure and stop one.
What other medicines interact with Hydrochlorothiazide-telmisartan?
MediHelp also lists interactions of Hydrochlorothiazide-telmisartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-telmisartan page.
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