Drug interactions
Hydrochlorothiazide-valsartan + Ibuprofen
Severity: Major
Hydrochlorothiazide-valsartan and Ibuprofen: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ibuprofen can blunt the antihypertensive effect of valsartan and hydrochlorothiazide. In combination with a diuretic and an angiotensin receptor blocker it also raises the risk of acute kidney injury, especially in older or volume-depleted patients, and may cause hyperkalemia.
What this interaction means in plain words
Hydrochlorothiazide-valsartan and Ibuprofen can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Hydrochlorothiazide-valsartan belongs to Cardiovascular; Ibuprofen belongs to Musculoskeletal.
Why it happens
NSAID inhibition of renal prostaglandins reduces afferent arteriolar dilation and sodium excretion, which together with angiotensin receptor blockade and diuretic-induced volume loss reduces glomerular filtration.
What to do
Avoid regular NSAID use where possible and use paracetamol or another alternative. If it cannot be avoided, keep the dose and duration low, ensure hydration, and monitor blood pressure, creatinine and potassium.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Hydrochlorothiazide-valsartan
- Aliskiren + Hydrochlorothiazide-valsartan Contraindicated
- Dofetilide + Hydrochlorothiazide-valsartan Contraindicated
- Hydrochlorothiazide-valsartan + Sparsentan Contraindicated
- Aldesleukin + Hydrochlorothiazide-valsartan Major
- Amifostine + Hydrochlorothiazide-valsartan Major
- Amiloride + Hydrochlorothiazide-valsartan Major
Other interactions of Ibuprofen
- Ibuprofen + Ketorolac Contraindicated
- Ibuprofen + Ketorolac intranasal Contraindicated
- Acemetacin + Ibuprofen Major
- Alteplase + Ibuprofen Major
- Amiloride + Ibuprofen Major
- Apixaban + Ibuprofen Major
Frequently asked questions
Can I take Hydrochlorothiazide-valsartan with Ibuprofen?
MediHelp rates the interaction as major. Hydrochlorothiazide-valsartan and Ibuprofen can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Ibuprofen can blunt the antihypertensive effect of valsartan and hydrochlorothiazide. In combination with a diuretic and an angiotensin receptor blocker it also raises the risk of acute kidney injury, especially in older or volume-depleted patients, and may cause hyperkalemia.
How serious is the interaction between Hydrochlorothiazide-valsartan and Ibuprofen?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid regular NSAID use where possible and use paracetamol or another alternative. If it cannot be avoided, keep the dose and duration low, ensure hydration, and monitor blood pressure, creatinine and potassium.
What other medicines interact with Hydrochlorothiazide-valsartan?
MediHelp also lists interactions of Hydrochlorothiazide-valsartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-valsartan page.
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