Drug interactions
Hydrochlorothiazide-valsartan + Insulin degludec
Severity: Moderate
Hydrochlorothiazide-valsartan and Insulin degludec: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Thiazide diuretics can raise blood glucose and may reduce the effectiveness of insulin in patients with diabetes. Valsartan may slightly improve insulin sensitivity, so the net effect on glycemic control varies between patients.
What this interaction means in plain words
Hydrochlorothiazide-valsartan and Insulin degludec can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Hydrochlorothiazide-valsartan belongs to Cardiovascular; Insulin degludec belongs to Endocrine.
Why it happens
Thiazide-induced reduction in insulin sensitivity and insulin release, partly related to potassium depletion, opposes insulin action.
What to do
Monitor blood glucose when the diuretic is started, changed or stopped, and titrate insulin degludec accordingly. Keep potassium in the normal range.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide-valsartan
- Aliskiren + Hydrochlorothiazide-valsartan Contraindicated
- Dofetilide + Hydrochlorothiazide-valsartan Contraindicated
- Hydrochlorothiazide-valsartan + Sparsentan Contraindicated
- Aldesleukin + Hydrochlorothiazide-valsartan Major
- Amifostine + Hydrochlorothiazide-valsartan Major
- Amiloride + Hydrochlorothiazide-valsartan Major
Other interactions of Insulin degludec
Frequently asked questions
Can I take Hydrochlorothiazide-valsartan with Insulin degludec?
MediHelp rates the interaction as moderate. Hydrochlorothiazide-valsartan and Insulin degludec can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Thiazide diuretics can raise blood glucose and may reduce the effectiveness of insulin in patients with diabetes. Valsartan may slightly improve insulin sensitivity, so the net effect on glycemic control varies between patients.
How serious is the interaction between Hydrochlorothiazide-valsartan and Insulin degludec?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when the diuretic is started, changed or stopped, and titrate insulin degludec accordingly. Keep potassium in the normal range.
What other medicines interact with Hydrochlorothiazide-valsartan?
MediHelp also lists interactions of Hydrochlorothiazide-valsartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-valsartan page.
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