Drug interactions
Hydrochlorothiazide-valsartan + Ketoconazole
Severity: Minor
Hydrochlorothiazide-valsartan and Ketoconazole: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Valsartan is a substrate of hepatic uptake transporters, and inhibition by ketoconazole could increase its exposure. Valsartan is mostly excreted unchanged and metabolized little, so clinically meaningful effects are unlikely.
What this interaction means in plain words
Hydrochlorothiazide-valsartan and Ketoconazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Hydrochlorothiazide-valsartan belongs to Cardiovascular; Ketoconazole belongs to Anti Fungals.
Why it happens
Possible inhibition of OATP1B1-mediated hepatic uptake of valsartan; evidence is mainly in vitro.
What to do
No dose adjustment is generally required. Monitor blood pressure if ketoconazole is started.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Hydrochlorothiazide-valsartan
- Aliskiren + Hydrochlorothiazide-valsartan Contraindicated
- Dofetilide + Hydrochlorothiazide-valsartan Contraindicated
- Hydrochlorothiazide-valsartan + Sparsentan Contraindicated
- Aldesleukin + Hydrochlorothiazide-valsartan Major
- Amifostine + Hydrochlorothiazide-valsartan Major
- Amiloride + Hydrochlorothiazide-valsartan Major
Other interactions of Ketoconazole
- Alfuzosin + Ketoconazole Contraindicated
- Alprazolam + Ketoconazole Contraindicated
- Avanafil + Ketoconazole Contraindicated
- Conivaptan + Ketoconazole Contraindicated
- Dihydroergotamine intranasal + Ketoconazole Contraindicated
- Dihydroergotamine + Ketoconazole Contraindicated
Frequently asked questions
Can I take Hydrochlorothiazide-valsartan with Ketoconazole?
MediHelp rates the interaction as minor. Hydrochlorothiazide-valsartan and Ketoconazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Valsartan is a substrate of hepatic uptake transporters, and inhibition by ketoconazole could increase its exposure. Valsartan is mostly excreted unchanged and metabolized little, so clinically meaningful effects are unlikely.
How serious is the interaction between Hydrochlorothiazide-valsartan and Ketoconazole?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is generally required. Monitor blood pressure if ketoconazole is started.
What other medicines interact with Hydrochlorothiazide-valsartan?
MediHelp also lists interactions of Hydrochlorothiazide-valsartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-valsartan page.
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