Drug interactions
Hydrochlorothiazide-valsartan + Magnesium citrate
Severity: Minor
Hydrochlorothiazide-valsartan and Magnesium citrate: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Thiazide diuretics promote urinary magnesium loss and can lead to hypomagnesemia during long-term use. Magnesium supplements may partly offset this loss, so the pairing is generally not harmful and mainly matters for electrolyte balance.
What this interaction means in plain words
Hydrochlorothiazide-valsartan and Magnesium citrate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Hydrochlorothiazide-valsartan belongs to Cardiovascular; Magnesium citrate belongs to Gastrointestinal Tract.
Why it happens
Hydrochlorothiazide increases renal magnesium excretion, opposing the effect of magnesium supplementation.
What to do
No dose change is usually needed; check serum magnesium periodically in patients on long-term thiazide therapy, especially with renal impairment where magnesium may accumulate.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Hydrochlorothiazide-valsartan
- Aliskiren + Hydrochlorothiazide-valsartan Contraindicated
- Dofetilide + Hydrochlorothiazide-valsartan Contraindicated
- Hydrochlorothiazide-valsartan + Sparsentan Contraindicated
- Aldesleukin + Hydrochlorothiazide-valsartan Major
- Amifostine + Hydrochlorothiazide-valsartan Major
- Amiloride + Hydrochlorothiazide-valsartan Major
Other interactions of Magnesium citrate
- Ciprofloxacin + Magnesium citrate Major
- Baloxavir marboxil + Magnesium citrate Moderate
- Bictegravir + Magnesium citrate Moderate
- Cabotegravir + Magnesium citrate Moderate
- Cholecalciferol + Magnesium citrate Moderate
- Deferiprone + Magnesium citrate Moderate
Frequently asked questions
Can I take Hydrochlorothiazide-valsartan with Magnesium citrate?
MediHelp rates the interaction as minor. Hydrochlorothiazide-valsartan and Magnesium citrate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Thiazide diuretics promote urinary magnesium loss and can lead to hypomagnesemia during long-term use. Magnesium supplements may partly offset this loss, so the pairing is generally not harmful and mainly matters for electrolyte balance.
How serious is the interaction between Hydrochlorothiazide-valsartan and Magnesium citrate?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is usually needed; check serum magnesium periodically in patients on long-term thiazide therapy, especially with renal impairment where magnesium may accumulate.
What other medicines interact with Hydrochlorothiazide-valsartan?
MediHelp also lists interactions of Hydrochlorothiazide-valsartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-valsartan page.
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