Drug interactions
Hydrochlorothiazide-valsartan + Meloxicam
Severity: Moderate
Hydrochlorothiazide-valsartan and Meloxicam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Meloxicam can reduce the blood pressure lowering effect of valsartan and hydrochlorothiazide. Together with an ARB and a diuretic it increases the risk of acute kidney injury and hyperkalemia, particularly in older or volume-depleted patients.
What this interaction means in plain words
Hydrochlorothiazide-valsartan and Meloxicam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Hydrochlorothiazide-valsartan belongs to Cardiovascular; Meloxicam belongs to Musculoskeletal.
Why it happens
Inhibition of renal prostaglandin synthesis causes sodium and water retention and reduced glomerular perfusion, which counteracts the antihypertensive effect and impairs renal function when combined with ARB and diuretic.
What to do
Use the lowest effective NSAID dose for the shortest time and keep the patient hydrated. Monitor blood pressure, serum creatinine and potassium, especially at initiation.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide-valsartan
- Aliskiren + Hydrochlorothiazide-valsartan Contraindicated
- Dofetilide + Hydrochlorothiazide-valsartan Contraindicated
- Hydrochlorothiazide-valsartan + Sparsentan Contraindicated
- Aldesleukin + Hydrochlorothiazide-valsartan Major
- Amifostine + Hydrochlorothiazide-valsartan Major
- Amiloride + Hydrochlorothiazide-valsartan Major
Other interactions of Meloxicam
- Ketorolac intranasal + Meloxicam Contraindicated
- Ketorolac + Meloxicam Contraindicated
- Aceclofenac + Meloxicam Major
- Acemetacin + Meloxicam Major
- Acetylsalicylic acid + Meloxicam Major
- Alteplase + Meloxicam Major
Frequently asked questions
Can I take Hydrochlorothiazide-valsartan with Meloxicam?
MediHelp rates the interaction as moderate. Hydrochlorothiazide-valsartan and Meloxicam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Meloxicam can reduce the blood pressure lowering effect of valsartan and hydrochlorothiazide. Together with an ARB and a diuretic it increases the risk of acute kidney injury and hyperkalemia, particularly in older or volume-depleted patients.
How serious is the interaction between Hydrochlorothiazide-valsartan and Meloxicam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective NSAID dose for the shortest time and keep the patient hydrated. Monitor blood pressure, serum creatinine and potassium, especially at initiation.
What other medicines interact with Hydrochlorothiazide-valsartan?
MediHelp also lists interactions of Hydrochlorothiazide-valsartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-valsartan page.
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