Drug interactions
Hydrochlorothiazide-valsartan + Nelfinavir
Severity: Moderate
Hydrochlorothiazide-valsartan and Nelfinavir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Valsartan is taken up into the liver by OATP1B1 and eliminated via MRP2, so inhibitors of these transporters may raise its exposure. Nelfinavir has been proposed to do this, which could enhance hypotension or renal effects. The evidence is mainly in vitro and inferred.
What this interaction means in plain words
Hydrochlorothiazide-valsartan and Nelfinavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Hydrochlorothiazide-valsartan belongs to Cardiovascular; Nelfinavir belongs to Anti Virals.
Why it happens
Possible inhibition of hepatic uptake (OATP1B1) and efflux transport of valsartan by nelfinavir, increasing systemic exposure.
What to do
Monitor blood pressure, renal function and potassium when starting or stopping nelfinavir; reduce the valsartan dose if hypotension occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide-valsartan
- Aliskiren + Hydrochlorothiazide-valsartan Contraindicated
- Dofetilide + Hydrochlorothiazide-valsartan Contraindicated
- Hydrochlorothiazide-valsartan + Sparsentan Contraindicated
- Aldesleukin + Hydrochlorothiazide-valsartan Major
- Amifostine + Hydrochlorothiazide-valsartan Major
- Amiloride + Hydrochlorothiazide-valsartan Major
Other interactions of Nelfinavir
- Alfuzosin + Nelfinavir Contraindicated
- Avanafil + Nelfinavir Contraindicated
- Dronedarone + Nelfinavir Contraindicated
- Eletriptan + Nelfinavir Contraindicated
- Ergotamine + Nelfinavir Contraindicated
- Flibanserin + Nelfinavir Contraindicated
Frequently asked questions
Can I take Hydrochlorothiazide-valsartan with Nelfinavir?
MediHelp rates the interaction as moderate. Hydrochlorothiazide-valsartan and Nelfinavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Valsartan is taken up into the liver by OATP1B1 and eliminated via MRP2, so inhibitors of these transporters may raise its exposure. Nelfinavir has been proposed to do this, which could enhance hypotension or renal effects. The evidence is mainly in vitro and inferred.
How serious is the interaction between Hydrochlorothiazide-valsartan and Nelfinavir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, renal function and potassium when starting or stopping nelfinavir; reduce the valsartan dose if hypotension occurs.
What other medicines interact with Hydrochlorothiazide-valsartan?
MediHelp also lists interactions of Hydrochlorothiazide-valsartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-valsartan page.
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