Drug interactions
Hydrochlorothiazide-valsartan + Quinine
Severity: Moderate
Hydrochlorothiazide-valsartan and Quinine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Quinine can prolong the QT interval, and hypokalemia or hypomagnesemia from hydrochlorothiazide may increase the risk of torsades de pointes. The interaction is driven by electrolyte disturbance rather than altered quinine clearance.
What this interaction means in plain words
Hydrochlorothiazide-valsartan and Quinine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Hydrochlorothiazide-valsartan belongs to Cardiovascular; Quinine belongs to Anti Parasitic.
Why it happens
Thiazide-induced hypokalemia and hypomagnesemia add to quinine-related QT prolongation.
What to do
Check and correct potassium and magnesium before and during quinine therapy, and obtain an ECG in patients with other QT risk factors.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide-valsartan
- Aliskiren + Hydrochlorothiazide-valsartan Contraindicated
- Dofetilide + Hydrochlorothiazide-valsartan Contraindicated
- Hydrochlorothiazide-valsartan + Sparsentan Contraindicated
- Aldesleukin + Hydrochlorothiazide-valsartan Major
- Amifostine + Hydrochlorothiazide-valsartan Major
- Amiloride + Hydrochlorothiazide-valsartan Major
Other interactions of Quinine
- Arsenic trioxide + Quinine Contraindicated
- Dofetilide + Quinine Contraindicated
- Dronedarone + Quinine Contraindicated
- Ibutilide + Quinine Contraindicated
- Mefloquine + Quinine Contraindicated
- Nilotinib + Quinine Contraindicated
Frequently asked questions
Can I take Hydrochlorothiazide-valsartan with Quinine?
MediHelp rates the interaction as moderate. Hydrochlorothiazide-valsartan and Quinine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Quinine can prolong the QT interval, and hypokalemia or hypomagnesemia from hydrochlorothiazide may increase the risk of torsades de pointes. The interaction is driven by electrolyte disturbance rather than altered quinine clearance.
How serious is the interaction between Hydrochlorothiazide-valsartan and Quinine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check and correct potassium and magnesium before and during quinine therapy, and obtain an ECG in patients with other QT risk factors.
What other medicines interact with Hydrochlorothiazide-valsartan?
MediHelp also lists interactions of Hydrochlorothiazide-valsartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-valsartan page.
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