Drug interactions
Hydrochlorothiazide-valsartan + Salmeterol
Severity: Moderate
Hydrochlorothiazide-valsartan and Salmeterol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both hydrochlorothiazide and salmeterol can lower serum potassium. Combined use, particularly with high-dose salmeterol or in patients with hypoxia, may produce clinically significant hypokalemia and raise arrhythmia risk. Valsartan partly offsets potassium loss.
What this interaction means in plain words
Hydrochlorothiazide-valsartan and Salmeterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Hydrochlorothiazide-valsartan belongs to Cardiovascular; Salmeterol belongs to Respiratory.
Why it happens
Additive hypokalemia from thiazide-induced renal potassium wasting and beta-2 agonist-driven intracellular potassium shift.
What to do
Monitor serum potassium in patients with risk factors such as heart disease, hypoxia or high-dose beta-agonist use. Replace potassium if levels are low.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide-valsartan
- Aliskiren + Hydrochlorothiazide-valsartan Contraindicated
- Dofetilide + Hydrochlorothiazide-valsartan Contraindicated
- Hydrochlorothiazide-valsartan + Sparsentan Contraindicated
- Aldesleukin + Hydrochlorothiazide-valsartan Major
- Amifostine + Hydrochlorothiazide-valsartan Major
- Amiloride + Hydrochlorothiazide-valsartan Major
Other interactions of Salmeterol
- Ritonavir + Salmeterol Contraindicated
- Salmeterol + Saquinavir Contraindicated
- Amitriptyline + Salmeterol Major
- Arformoterol + Salmeterol Major
- Atazanavir + Salmeterol Major
- Budesonide-formoterol + Salmeterol Major
Frequently asked questions
Can I take Hydrochlorothiazide-valsartan with Salmeterol?
MediHelp rates the interaction as moderate. Hydrochlorothiazide-valsartan and Salmeterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both hydrochlorothiazide and salmeterol can lower serum potassium. Combined use, particularly with high-dose salmeterol or in patients with hypoxia, may produce clinically significant hypokalemia and raise arrhythmia risk. Valsartan partly offsets potassium loss.
How serious is the interaction between Hydrochlorothiazide-valsartan and Salmeterol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium in patients with risk factors such as heart disease, hypoxia or high-dose beta-agonist use. Replace potassium if levels are low.
What other medicines interact with Hydrochlorothiazide-valsartan?
MediHelp also lists interactions of Hydrochlorothiazide-valsartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-valsartan page.
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