Drug interactions
Hydrochlorothiazide-valsartan + Tadalafil
Severity: Moderate
Hydrochlorothiazide-valsartan and Tadalafil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tadalafil has vasodilatory activity and can add to the blood pressure lowering of valsartan and hydrochlorothiazide. Symptomatic hypotension, dizziness or syncope may occur, particularly in volume-depleted or older patients.
What this interaction means in plain words
Hydrochlorothiazide-valsartan and Tadalafil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Hydrochlorothiazide-valsartan belongs to Cardiovascular; Tadalafil belongs to Genitourinary.
Why it happens
Additive vasodilation from PDE5 inhibition combined with antihypertensive agents.
What to do
Start tadalafil at a low dose and counsel on orthostatic symptoms. Monitor blood pressure, especially after initiation or dose changes.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide-valsartan
- Aliskiren + Hydrochlorothiazide-valsartan Contraindicated
- Dofetilide + Hydrochlorothiazide-valsartan Contraindicated
- Hydrochlorothiazide-valsartan + Sparsentan Contraindicated
- Aldesleukin + Hydrochlorothiazide-valsartan Major
- Amifostine + Hydrochlorothiazide-valsartan Major
- Amiloride + Hydrochlorothiazide-valsartan Major
Other interactions of Tadalafil
- Amyl nitrite + Tadalafil Contraindicated
- Isosorbide dinitrate + Tadalafil Contraindicated
- Isosorbide mononitrate + Tadalafil Contraindicated
- Nitroglycerin po + Tadalafil Contraindicated
- Nitroglycerin rectal + Tadalafil Contraindicated
- Nitroglycerin sublingual + Tadalafil Contraindicated
Frequently asked questions
Can I take Hydrochlorothiazide-valsartan with Tadalafil?
MediHelp rates the interaction as moderate. Hydrochlorothiazide-valsartan and Tadalafil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tadalafil has vasodilatory activity and can add to the blood pressure lowering of valsartan and hydrochlorothiazide. Symptomatic hypotension, dizziness or syncope may occur, particularly in volume-depleted or older patients.
How serious is the interaction between Hydrochlorothiazide-valsartan and Tadalafil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start tadalafil at a low dose and counsel on orthostatic symptoms. Monitor blood pressure, especially after initiation or dose changes.
What other medicines interact with Hydrochlorothiazide-valsartan?
MediHelp also lists interactions of Hydrochlorothiazide-valsartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-valsartan page.
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