Drug interactions
Hydrochlorothiazide-valsartan + Timolol
Severity: Moderate
Hydrochlorothiazide-valsartan and Timolol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Timolol, a beta-blocker, adds to the antihypertensive effect of valsartan and hydrochlorothiazide, which may cause hypotension or bradycardia. Beta-blockers can also slightly raise potassium. Ophthalmic timolol has less systemic effect but can still contribute in susceptible patients.
What this interaction means in plain words
Hydrochlorothiazide-valsartan and Timolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Hydrochlorothiazide-valsartan belongs to Cardiovascular; Timolol belongs to Cardiovascular.
Why it happens
Additive pharmacodynamic blood pressure lowering through beta-blockade, RAS inhibition and diuresis.
What to do
Monitor blood pressure and heart rate when starting or adjusting therapy. Adjust doses if symptomatic hypotension or bradycardia develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide-valsartan
- Aliskiren + Hydrochlorothiazide-valsartan Contraindicated
- Dofetilide + Hydrochlorothiazide-valsartan Contraindicated
- Hydrochlorothiazide-valsartan + Sparsentan Contraindicated
- Aldesleukin + Hydrochlorothiazide-valsartan Major
- Amifostine + Hydrochlorothiazide-valsartan Major
- Amiloride + Hydrochlorothiazide-valsartan Major
Other interactions of Timolol
- Acebutolol + Timolol Major
- Albuterol + Timolol Major
- Aldesleukin + Timolol Major
- Amifostine + Timolol Major
- Amiodarone + Timolol Major
- Arformoterol + Timolol Major
Frequently asked questions
Can I take Hydrochlorothiazide-valsartan with Timolol?
MediHelp rates the interaction as moderate. Hydrochlorothiazide-valsartan and Timolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Timolol, a beta-blocker, adds to the antihypertensive effect of valsartan and hydrochlorothiazide, which may cause hypotension or bradycardia. Beta-blockers can also slightly raise potassium. Ophthalmic timolol has less systemic effect but can still contribute in susceptible patients.
How serious is the interaction between Hydrochlorothiazide-valsartan and Timolol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate when starting or adjusting therapy. Adjust doses if symptomatic hypotension or bradycardia develops.
What other medicines interact with Hydrochlorothiazide-valsartan?
MediHelp also lists interactions of Hydrochlorothiazide-valsartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-valsartan page.
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