Drug interactions
Hydrochlorothiazide-valsartan + Tretinoin
Severity: Minor
Hydrochlorothiazide-valsartan and Tretinoin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Hydrochlorothiazide is photosensitizing, and tretinoin, particularly topical, makes skin more sensitive to sunlight. Together they may increase sunburn or phototoxic reactions, but the effect is usually manageable.
What this interaction means in plain words
Hydrochlorothiazide-valsartan and Tretinoin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Hydrochlorothiazide-valsartan belongs to Cardiovascular; Tretinoin belongs to Dermatology.
Why it happens
Additive photosensitizing effects on the skin; no pharmacokinetic interaction is established.
What to do
Advise strict sun protection with sunscreen and protective clothing while both are used. Reduce tretinoin use if skin irritation or sunburn occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Hydrochlorothiazide-valsartan
- Aliskiren + Hydrochlorothiazide-valsartan Contraindicated
- Dofetilide + Hydrochlorothiazide-valsartan Contraindicated
- Hydrochlorothiazide-valsartan + Sparsentan Contraindicated
- Aldesleukin + Hydrochlorothiazide-valsartan Major
- Amifostine + Hydrochlorothiazide-valsartan Major
- Amiloride + Hydrochlorothiazide-valsartan Major
Other interactions of Tretinoin
- Doxycycline + Tretinoin Major
- Minocycline + Tretinoin Major
- Omadacycline + Tretinoin Major
- Palovarotene + Tretinoin Major
- Sarecycline + Tretinoin Major
- Tetracycline + Tretinoin Major
Frequently asked questions
Can I take Hydrochlorothiazide-valsartan with Tretinoin?
MediHelp rates the interaction as minor. Hydrochlorothiazide-valsartan and Tretinoin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Hydrochlorothiazide is photosensitizing, and tretinoin, particularly topical, makes skin more sensitive to sunlight. Together they may increase sunburn or phototoxic reactions, but the effect is usually manageable.
How serious is the interaction between Hydrochlorothiazide-valsartan and Tretinoin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise strict sun protection with sunscreen and protective clothing while both are used. Reduce tretinoin use if skin irritation or sunburn occurs.
What other medicines interact with Hydrochlorothiazide-valsartan?
MediHelp also lists interactions of Hydrochlorothiazide-valsartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-valsartan page.
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