Drug interactions
Hydrocodone + Lorcaserin
Severity: Moderate
Hydrocodone and Lorcaserin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lorcaserin is a serotonin 5-HT2C agonist, and use with serotonergic agents including opioids may theoretically cause serotonin syndrome. Evidence is mainly from labeling warnings rather than reported cases with hydrocodone. Lorcaserin has been withdrawn from the US market.
What this interaction means in plain words
Hydrocodone and Lorcaserin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Theoretical additive serotonergic stimulation.
What to do
If used together, monitor for serotonin syndrome symptoms, particularly at initiation or dose changes, and discontinue if they occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrocodone
- Alvimopan + Hydrocodone Contraindicated
- Bupropion-naltrexone + Hydrocodone Contraindicated
- Hydrocodone + Isocarboxazid Contraindicated
- Hydrocodone + Olanzapine / samidorphan Contraindicated
- Hydrocodone + Phenelzine Contraindicated
- Alfentanil + Hydrocodone Major
Frequently asked questions
Can I take Hydrocodone with Lorcaserin?
MediHelp rates the interaction as moderate. Hydrocodone and Lorcaserin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lorcaserin is a serotonin 5-HT2C agonist, and use with serotonergic agents including opioids may theoretically cause serotonin syndrome. Evidence is mainly from labeling warnings rather than reported cases with hydrocodone. Lorcaserin has been withdrawn from the US market.
How serious is the interaction between Hydrocodone and Lorcaserin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: If used together, monitor for serotonin syndrome symptoms, particularly at initiation or dose changes, and discontinue if they occur.
What other medicines interact with Hydrocodone?
MediHelp also lists interactions of Hydrocodone with, for example, Alvimopan, Bupropion-naltrexone, Isocarboxazid. The full list is on the Hydrocodone page.
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