Drug interactions
Hydrocodone + Nafcillin
Severity: Moderate
Hydrocodone and Nafcillin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nafcillin may induce CYP3A4 and lower hydrocodone exposure, potentially reducing pain control. Stopping nafcillin after the dose has been raised may lead to opioid accumulation and respiratory depression.
What this interaction means in plain words
Hydrocodone and Nafcillin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Nafcillin induces CYP3A4, increasing hydrocodone clearance.
What to do
Monitor pain control during nafcillin therapy and adjust the dose as needed. When nafcillin is stopped, reduce hydrocodone as indicated and monitor for sedation and respiratory depression.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrocodone
- Alvimopan + Hydrocodone Contraindicated
- Bupropion-naltrexone + Hydrocodone Contraindicated
- Hydrocodone + Isocarboxazid Contraindicated
- Hydrocodone + Olanzapine / samidorphan Contraindicated
- Hydrocodone + Phenelzine Contraindicated
- Alfentanil + Hydrocodone Major
Frequently asked questions
Can I take Hydrocodone with Nafcillin?
MediHelp rates the interaction as moderate. Hydrocodone and Nafcillin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nafcillin may induce CYP3A4 and lower hydrocodone exposure, potentially reducing pain control. Stopping nafcillin after the dose has been raised may lead to opioid accumulation and respiratory depression.
How serious is the interaction between Hydrocodone and Nafcillin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor pain control during nafcillin therapy and adjust the dose as needed. When nafcillin is stopped, reduce hydrocodone as indicated and monitor for sedation and respiratory depression.
What other medicines interact with Hydrocodone?
MediHelp also lists interactions of Hydrocodone with, for example, Alvimopan, Bupropion-naltrexone, Isocarboxazid. The full list is on the Hydrocodone page.
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