Drug interactions
Hydrocodone + Sumatriptan intranasal
Severity: Minor
Hydrocodone and Sumatriptan intranasal: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Triptans combined with opioids have been associated with serotonin syndrome in labeling warnings, though reports are rare and hydrocodone has limited serotonergic activity. Symptoms include agitation, tremor, sweating, and hyperreflexia.
What this interaction means in plain words
Hydrocodone and Sumatriptan intranasal have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Theoretical additive serotonergic effect via 5-HT1B/1D agonism plus opioid activity.
What to do
Counsel on serotonin syndrome symptoms and discontinue if they appear. No routine dose change is needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Hydrocodone
- Alvimopan + Hydrocodone Contraindicated
- Bupropion-naltrexone + Hydrocodone Contraindicated
- Hydrocodone + Isocarboxazid Contraindicated
- Hydrocodone + Olanzapine / samidorphan Contraindicated
- Hydrocodone + Phenelzine Contraindicated
- Alfentanil + Hydrocodone Major
Frequently asked questions
Can I take Hydrocodone with Sumatriptan intranasal?
MediHelp rates the interaction as minor. Hydrocodone and Sumatriptan intranasal have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Triptans combined with opioids have been associated with serotonin syndrome in labeling warnings, though reports are rare and hydrocodone has limited serotonergic activity. Symptoms include agitation, tremor, sweating, and hyperreflexia.
How serious is the interaction between Hydrocodone and Sumatriptan intranasal?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel on serotonin syndrome symptoms and discontinue if they appear. No routine dose change is needed.
What other medicines interact with Hydrocodone?
MediHelp also lists interactions of Hydrocodone with, for example, Alvimopan, Bupropion-naltrexone, Isocarboxazid. The full list is on the Hydrocodone page.
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