Drug interactions
Hydrocodone + Triazolam
Severity: Major
Hydrocodone and Triazolam: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Benzodiazepines combined with opioids carry a boxed warning for profound sedation, respiratory depression, coma and death. Triazolam is a short-acting hypnotic with potent effects, and its CYP3A4 metabolism is shared with hydrocodone.
What this interaction means in plain words
Hydrocodone and Triazolam can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive CNS and respiratory depression from GABA-A potentiation and mu-opioid agonism.
What to do
Avoid unless alternatives are inadequate; use the lowest doses for the shortest time and monitor for sedation and respiratory depression. Consider providing naloxone.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Hydrocodone
- Alvimopan + Hydrocodone Contraindicated
- Bupropion-naltrexone + Hydrocodone Contraindicated
- Hydrocodone + Isocarboxazid Contraindicated
- Hydrocodone + Olanzapine / samidorphan Contraindicated
- Hydrocodone + Phenelzine Contraindicated
- Alfentanil + Hydrocodone Major
Frequently asked questions
Can I take Hydrocodone with Triazolam?
MediHelp rates the interaction as major. Hydrocodone and Triazolam can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Benzodiazepines combined with opioids carry a boxed warning for profound sedation, respiratory depression, coma and death. Triazolam is a short-acting hypnotic with potent effects, and its CYP3A4 metabolism is shared with hydrocodone.
How serious is the interaction between Hydrocodone and Triazolam?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid unless alternatives are inadequate; use the lowest doses for the shortest time and monitor for sedation and respiratory depression. Consider providing naloxone.
What other medicines interact with Hydrocodone?
MediHelp also lists interactions of Hydrocodone with, for example, Alvimopan, Bupropion-naltrexone, Isocarboxazid. The full list is on the Hydrocodone page.
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