Drug interactions
Hydrocortisone + Lapatinib
Severity: Moderate
Hydrocortisone and Lapatinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lapatinib inhibits CYP3A4 and P-glycoprotein and may increase hydrocortisone exposure, while corticosteroids may weakly induce CYP3A4 and lower lapatinib levels. The net effect is uncertain, but a reduction in lapatinib exposure could affect anticancer efficacy.
What this interaction means in plain words
Hydrocortisone and Lapatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Hydrocortisone belongs to Endocrine; Lapatinib belongs to Oncology.
Why it happens
Bidirectional CYP3A4 and P-glycoprotein effects: lapatinib inhibition of hydrocortisone clearance and possible weak induction of lapatinib metabolism by hydrocortisone.
What to do
Monitor for corticosteroid excess and for lapatinib efficacy and toxicity; avoid prolonged high-dose systemic corticosteroids where possible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrocortisone
- Hydrocortisone + Mifepristone Contraindicated
- Hydrocortisone + Poliovirus vaccine live oral trivalent Contraindicated
- Hydrocortisone + Smallpox vaccine live Contraindicated
- Adenovirus types 4 and 7 live + Hydrocortisone Major
- Aldesleukin + Hydrocortisone Major
- Aspirin + Hydrocortisone Major
Other interactions of Lapatinib
- Dofetilide + Lapatinib Contraindicated
- Ibutilide + Lapatinib Contraindicated
- Lapatinib + Pimozide Contraindicated
- Lapatinib + Saquinavir Contraindicated
- Lapatinib + Thioridazine Contraindicated
- Adagrasib + Lapatinib Major
Frequently asked questions
Can I take Hydrocortisone with Lapatinib?
MediHelp rates the interaction as moderate. Hydrocortisone and Lapatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lapatinib inhibits CYP3A4 and P-glycoprotein and may increase hydrocortisone exposure, while corticosteroids may weakly induce CYP3A4 and lower lapatinib levels. The net effect is uncertain, but a reduction in lapatinib exposure could affect anticancer efficacy.
How serious is the interaction between Hydrocortisone and Lapatinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for corticosteroid excess and for lapatinib efficacy and toxicity; avoid prolonged high-dose systemic corticosteroids where possible.
What other medicines interact with Hydrocortisone?
MediHelp also lists interactions of Hydrocortisone with, for example, Mifepristone, Poliovirus vaccine live oral trivalent, Smallpox vaccine live. The full list is on the Hydrocortisone page.
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