Drug interactions
Hydrocortisone + Memantine-donepezil
Severity: Minor
Hydrocortisone and Memantine-donepezil: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Hydrocortisone may induce CYP3A4 modestly and lower donepezil exposure. The effect is expected to be small and of limited clinical significance.
What this interaction means in plain words
Hydrocortisone and Memantine-donepezil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Hydrocortisone belongs to Endocrine; Memantine-donepezil belongs to Central Nervous System.
Why it happens
Corticosteroid-mediated CYP3A4 induction may increase donepezil metabolism.
What to do
No dose adjustment; reassess cognitive response if high-dose steroid therapy is prolonged.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Memantine-donepezil
- Dronedarone + Memantine-donepezil Contraindicated
- Memantine-donepezil + Thioridazine Contraindicated
- Amantadine + Memantine-donepezil Major
- Amiodarone + Memantine-donepezil Major
- Amisulpride + Memantine-donepezil Major
- Amitriptyline + Memantine-donepezil Major
Other interactions of Hydrocortisone
- Hydrocortisone + Mifepristone Contraindicated
- Hydrocortisone + Poliovirus vaccine live oral trivalent Contraindicated
- Hydrocortisone + Smallpox vaccine live Contraindicated
- Adenovirus types 4 and 7 live + Hydrocortisone Major
- Aldesleukin + Hydrocortisone Major
- Aspirin + Hydrocortisone Major
Frequently asked questions
Can I take Hydrocortisone with Memantine-donepezil?
MediHelp rates the interaction as minor. Hydrocortisone and Memantine-donepezil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Hydrocortisone may induce CYP3A4 modestly and lower donepezil exposure. The effect is expected to be small and of limited clinical significance.
How serious is the interaction between Hydrocortisone and Memantine-donepezil?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment; reassess cognitive response if high-dose steroid therapy is prolonged.
What other medicines interact with Memantine-donepezil?
MediHelp also lists interactions of Memantine-donepezil with, for example, Dronedarone, Thioridazine, Amantadine. The full list is on the Memantine-donepezil page.
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