Drug interactions
Hydrocortisone + Nicardipine
Severity: Minor
Hydrocortisone and Nicardipine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nicardipine is a CYP3A4 and P-glycoprotein inhibitor, so it could modestly raise corticosteroid exposure, while corticosteroids may weakly induce CYP3A4 and slightly lower nicardipine levels. Net effects are small and unpredictable.
What this interaction means in plain words
Hydrocortisone and Nicardipine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Hydrocortisone belongs to Endocrine; Nicardipine belongs to Cardiovascular.
Why it happens
Opposing weak effects on CYP3A4 and P-glycoprotein; the net impact is not well established.
What to do
No empirical dose change is needed. Monitor blood pressure and steroid effects when starting or stopping either drug.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Hydrocortisone
- Hydrocortisone + Mifepristone Contraindicated
- Hydrocortisone + Poliovirus vaccine live oral trivalent Contraindicated
- Hydrocortisone + Smallpox vaccine live Contraindicated
- Adenovirus types 4 and 7 live + Hydrocortisone Major
- Aldesleukin + Hydrocortisone Major
- Aspirin + Hydrocortisone Major
Other interactions of Nicardipine
Frequently asked questions
Can I take Hydrocortisone with Nicardipine?
MediHelp rates the interaction as minor. Hydrocortisone and Nicardipine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Nicardipine is a CYP3A4 and P-glycoprotein inhibitor, so it could modestly raise corticosteroid exposure, while corticosteroids may weakly induce CYP3A4 and slightly lower nicardipine levels. Net effects are small and unpredictable.
How serious is the interaction between Hydrocortisone and Nicardipine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No empirical dose change is needed. Monitor blood pressure and steroid effects when starting or stopping either drug.
What other medicines interact with Hydrocortisone?
MediHelp also lists interactions of Hydrocortisone with, for example, Mifepristone, Poliovirus vaccine live oral trivalent, Smallpox vaccine live. The full list is on the Hydrocortisone page.
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